Effective treatment for Parkinson's Disorder (PD) patients remains elusive. While Levadopa (l-dopa) is the most widely used antiparkinsonian medication, it also can induce dyskinesias, or movement disorders. This is the largest ever study to examine pathological changes in a
post-mortem PD cohort specifically separated according their dyskinetic
phenotype, thereby allowing a direct correlation of biochemical markers
with l-dopa–induced dyskinesias (LID) incidence and severity.
Reference: Cheshire P, Ayton S, Bertram KL, Ling H, Li A, McLean C, Halliday GM, O'Sullivan SS, Revesz T, Finkelstein DL, Storey E, Williams DR. Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias. Mov Disord. 2015 May;30(6):796-804. doi: 10.1002/mds.26144
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