 |
Figure 2. Molecular mechanisms for IL7R/JAK/STAT
activation in T-cell acute lymphoblastic leukemia (T-ALL). |
Review article on T-cell acute lymphoblastic leukemia (T-ALL), an aggressive type of blood cancer that accounts for about 15% of pediatric and 25% of adult acute lymphoblastic leukemia (ALL) cases. It is considered as a paradigm for the multistep nature of cancer initiation and progression. T-ALL originates from T-cell precursors at different stages of their development and is characterized by distinct and well characterized molecular genetic subtypes. Children affected by this disease respond fairly well to high-dose chemotherapy regimens. Unfortunately, the clinical response in adults remains problematic, and therapeutic options for relapsed T-ALL patients remain scarce.