Our paper in Experimental Neurology shows, for the first time, that mice which naturally produce high levels of tPA in the brain experience Purkinje damage. This observation suggests that "tPA" is, at least in part, responsible for Purkinje damage. Future research should now be aimed at reducing "tPA" in the brain and thereby preserving Purkinje health across an array of human neurological disorders such as Huntington's disease.
Cops EJ, Sashindranath M, Daglas M, Short KM, da Fonseca Pereira C, Pang TY, Lijnen RH, Smyth IM, Hannan AJ, Samson AL, Medcalf RL. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental Neurology, 9 August 2013.
Image: Medcalf lab. A close-up microscope image of the mouse brain. The "purkinje neurons" (which degenerate in many human neurodegenerative disorders including Huntington's Disease) are depicted in a green-yellow colour.