Professor Rob Medcalf said, "Liposomes are harmless structures that can stay in the blood stream for up to a day. They are now being used to carry drugs for therapeutic needs to increase the effectiveness of drugs that otherwise are cleared very fast from the blood. We showed that liposomes can selectively enter the damaged brain within a 6 hour time window after trauma. This has now paved the way to introduce drugs to improve outcome after trauma. By acting as mini Trojan horses, these drug laden liposomes provide a targeted drug delivery system to direct drugs to the place in need".
Liposomal drug delivery is an established technology as the cells can encapsulate and carry drugs inside themselves, and bind to specific targets, releasing the drug at that point. The drug carriers are called stealth liposomes because of their ability to evade detection by the immune system. The technique is used in a number of existing medications, and is being investigated for different kinds of drugs for various conditions.
Reference: Boyd BJ, Galle A, Daglas M, Rosenfeld JV, Medcalf R. Traumatic brain injury opens blood-brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect. Journal of Drug Targeting: 23(9), 21 October 2015, pp. 847-853