|Malaria kills over half a million people|
globally each year. Image: VectorBase
This review comprehensively analyzes both historical and recent studies in which synthetic carriers are used to deliver malaria vaccines. Furthermore, the requirements for a synthetic carrier, such as size, charge, and surface chemistry are reviewed in order to understand the design of effective particle-based vaccines against malaria, as well as providing general insights. Synthetic carriers have the ability to alter and direct the immune response, and a better control of particle properties will facilitate improved vaccine design in the near future.
Reference (full text): Powles L, Xiang SD, Selomulya C, Plebanski M. Vaccines (Basel). The Use of Synthetic Carriers in Malaria Vaccine Design. Vaccines (Basel). 2015 Oct 29;3(4):894-929. doi: 10.3390/vaccines3040894. Review. PMID: 26529028