By Dr Jodie Abramovitch
Autoimmune disease occurs when the immune system incorrectly recognises self-tissues and organs as being potentially dangerous - like a pathogen. The immune system attacks the tissue or organ – sometimes in an organ-specific manner (eg. type I diabetes) or sometimes in a multi-organ fashion (eg. lupus) – which leads to disease symptoms. What causes the onset of autoimmune disease is not well understood and, consequently, there is no cure with treatments predominantly aimed at relieving inflammatory symptoms.
|Elisha de Valle - first author of this study|
This study revealed that NF-κB1 has an essential role in controlling the function of Fo B cells, primarily to limit the production of inflammatory factor IL-6. In the absence of NF-κB1, the production of IL-6 becomes deregulated and severe autoimmune disease can occur. These conclusions further the understanding of the mechanisms that control IL-6 production and may lead to better management of patients with autoimmune disease.
Reference: de Valle E, Grigoriadis G, O'Reilly LA, Willis SN, Maxwell MJ, Corcoran LM, Tsantikos E, Cornish JK, Fairfax KA, Vasanthakumar A, Febbraio MA, Hibbs ML, Pellegrini M, Banerjee A, Hodgkin PD, Kallies A, Mackay F, Strasser A, Gerondakis S, Gugasyan R. NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med. 2016 Apr; 213:621-41.