15 Sep 2017

Recent CCS publications: 9-15 Sep 2017

Professor David Tarlinton, HOD Immunology and Pathology
has two articles in this week's publications roundup. Recently
published video of David describing the department's research
Recent publications for Central Clinical School affiliated authors in the following departments. Note, browse down this entry for details. Linked headings for each section are to the departments' home pages.
  • Australian Centre for Blood Diseases (ACBD)
  • Allergy, Immunology and Respiratory Medicine (AIRMed)
  • Anaesthesia and Perioperative Medicine
  • Diabetes
  • Gastroenterology
  • Immunology and Pathology
  • Infectious Diseases
  • Medicine
  • Monash Alfred Psychiatry research centre (MAPrc) 
  • National Trauma Research Institute
  • Surgery


Brumatti G, Lalaoui N, Wei AH, Silke J. 'Did He Who Made theLamb Make Thee?' New Developments in Treating the 'Fearful Symmetry' of AcuteMyeloid Leukemia. Trends Mol Med. 2017 Mar;23(3):264-281. doi: 10.1016/j.molmed.2017.01.005. Epub 2017 Feb 11.

Hein et al. Nguyen NN, Guthridge MA, Wei A. Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population. Blood. 2017 May 25;129(21):2882-2895. doi: 10.1182/blood-2016-05-718171. Epub 2017 Mar 10.

Niego B, Lee N, Larsson P, De Silva TM, Au AE, McCutcheon F, Medcalf RL. Selective inhibition of brain endothelial Rho-kinase-2 providesoptimal protection of an in vitro blood-brain barrier from tissue-typeplasminogen activator and plasmin. PLoS One. 2017 May 16;12(5):e0177332. doi: 10.1371/journal.pone.0177332. eCollection 2017.

Qiao J, Arthur JF, Gardiner EE, Andrews RK, Zeng L, Xu K. Regulation of platelet activation and thrombus formation by reactive oxygenspecies. Redox Biol. 2017 Sep 7;14:126-130. doi: 10.1016/j.redox.2017.08.021. [Epub ahead of print]

Tan P et al. Tiong IS, Pomilio G, Spencer A, Wei A. The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study. Oncotarget. 2016 Nov 29;8(32):52269-52280. doi: 10.18632/oncotarget.13699. eCollection 2017 Aug 8.

Ellis AK, Frankish CW, O'Hehir RE, Armstrong K, Steacy L, Larché M, Hafner RP. Treatment with grass allergen peptides improves symptomsof grass pollen-induced allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2017 Aug;140(2):486-496. doi: 10.1016/j.jaci.2016.11.043. Epub 2017 Feb 21.

Moonesinghe SR, Wong DJN, Farmer L, Shawyer R, Myles PS, Harris SK; SNAP-2 Project team and Steering Group. SNAP-2 EPICCS: the secondSprint National Anaesthesia Project-EPIdemiology of Critical Care afterSurgery: protocol for an international observational cohort study. BMJ Open. 2017 Sep 7;7(9):e017690. doi: 10.1136/bmjopen-2017-017690


Braun LA, Ou R, Kure C, Trang A, Rosenfeldt F. Prevalence ofZinc Deficiency in Cardiac Surgery Patients. Heart Lung Circ. 2017 Aug 14. pii:S1443-9506(17)31342-2. doi: 10.1016/j.hlc.2017.07.009. [Epub ahead of print]

Brennan E et al. Tikellis C, Jandeleit-Dahm KAM, Kantharidis P. Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis. Diabetes. 2017 Aug;66(8):2266-2277. doi: 10.2337/db16-1405. Epub 2017 May 9.

Rafehi H, Kaspi A, Ziemann M, Okabe J, Karagiannis TC, El-Osta A. Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes. Epigenetics. 2017 Sep 8:0. doi: 10.1080/15592294.2017.1371892. [Epub ahead of print]

Ying YL, Chen YC, Jandeleit-Dahm K, Peter K. GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes. Atherosclerosis. 2017 Aug 18. pii: S0021-9150(17)31228-5. doi: 10.1016/j.atherosclerosis.2017.08.006. [Epub ahead of print]


Gibson PR, Burgell R. Easing Concerns About the Low FODMAP Diet in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017 Sep 1. pii: S0016-5085(17)36088-2. doi: 10.1053/j.gastro.2017.08.055. [Epub ahead of print]

Philpott H, Nandurkar S, Royce SG, Thien F, Gibson PR. Allergy tests do not predict food triggers in adult patients with eosinophilicoesophagitis. A comprehensive prospective study using five modalities. Aliment Pharmacol Ther. 2016 Aug;44(3):223-33. doi: 10.1111/apt.13676. Epub 2016 Jun 1.

Ward MG et al. Thwaites PA, Hogg J, Rosella G, Gibson PR, Sparrow MP. Intra-patient variability in adalimumab drug levels within and between cycles in Crohn's disease. Aliment Pharmacol Ther. 2017 Apr;45(8):1135-1145. doi: 10.1111/apt.13992. Epub 2017 Feb 27.


Carrington EM, Tarlinton DM, Gray DH, Huntington ND, Zhan Y, Lew AM. The life and death of immune cell types: The role of BCL-2 anti-apoptotic molecules. Immunol Cell Biol. 2017 Sep 6. doi: 10.1038/icb.2017.72. [Epub ahead of print]

Daillère R et al. Plebanski M. Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 2016 Oct 18;45(4):931-943. doi: 10.1016/j.immuni.2016.09.009. Epub 2016 Oct 4.

Low MS, Tarlinton D. HIV Vaccines: One Step Closer. Trends Mol Med. 2017 Jan;23(1):1-3. doi: 10.1016/j.molmed.2016.10.006. Epub 2016 Nov 23.

Wilson AL, Plebanski M, Stephens AN. New trends in anti-cancer therapy: combining conventional chemotherapeutics with novel immunomodulators. Curr Med Chem. 2017 Aug 29. doi: 10.2174/0929867324666170830094922. [Epub ahead of print]

Infectious Diseases

Petoumenos K, Huang R, Hoy J, Bloch M, Templeton DJ, Baker D, Giles M, Law MG, Cooper DA. Prevalence of self-reported comorbidities in HIV positive and HIV negative men who have sex with men over 55 years-The Australian Positive & Peers Longevity Evaluation Study (APPLES). PLoS One. 2017 Sep 8;12(9):e0184583. doi: 10.1371/journal.pone.0184583. eCollection 2017.

Smibert OC, Trubiano JA, Cross GB, Hoy JF. Mycobacterium avium Complex Infection and Immune Reconstitution Inflammatory Syndrome Remain a Challenge in the Era of Effective Antiretroviral Therapy. AIDS Res Hum Retroviruses. 2017 Sep 6. doi: 10.1089/AID.2017.0030. [Epub ahead of print]

Spelman T, Pilcher DV, Cheng AC, Bull AL, Richards MJ, Worth LJ. Central line-associated bloodstream infections in Australian ICUs:evaluating modifiable and non-modifiable risks in Victorian healthcarefacilities. Epidemiol Infect. 2017 Sep 4:1-9. doi: 10.1017/S095026881700187X. [Epub ahead of print]

Grigg J, Worsley R, Thew C, Gurvich C, Thomas N, Kulkarni J. Antipsychotic-induced hyperprolactinemia: synthesis of world-wide guidelines and integrated recommendations for assessment, management and future research. Psychopharmacology (Berl). 2017 Sep 9. doi: 10.1007/s00213-017-4730-6. [Epub ahead of print]

Jablensky A et al. Kulkarni J. The 2016 RANZCP Guidelines for the Management of Schizophrenia and Related Disorders - what's next?  Australas Psychiatry. 2017 Sep 1:1039856217726691. doi:
10.1177/1039856217726691. [Epub ahead of print]


Adams HH et. Srikanth V. Novel genetic loci underlying humanintracranial volume identified through genome-wide association. Nat Neurosci. 2016 Dec;19(12):1569-1582. doi: 10.1038/nn.4398. Epub 2016 Oct 3.

Darido C, Georgy SR, Jane SM. The role of barrier genes inepidermal malignancy. Oncogene. 2016 Nov 3;35(44):5705-5712. doi: 10.1038/onc.2016.84. Epub 2016 Apr 4.


Chow EPF, Walker S, Read TRH, Chen MY, Bradshaw CS, Fairley CK. Self-Reported Use of Mouthwash and Pharyngeal Gonorrhoea Detection byNucleic Acid Amplification Test. Sex Transm Dis. 2017 Oct;44(10):593-595. doi: 10.1097/OLQ.0000000000000654.

Kong FY, Rupasinghe TW, Simpson JA, Vodstrcil LA, Fairley CK, McConville MJ, Hocking JS. Pharmacokinetics of a single 1g dose ofazithromycin in rectal tissue in men. PLoS One. 2017 Mar 28;12(3):e0174372. doi: 10.1371/journal.pone.0174372. eCollection 2017.

Vodstrcil LA, Rupasinghe TWT, Kong FYS, Tull HH, Worthington K, Chen MY, Huston WM, Timms P, McConville MJ, Fairley CK, Bradshaw CS, Tabrizi SN, Hocking JS. Measurement of tissue azithromycin levels in self-collectedvaginal swabs post treatment using liquid chromatography and tandem massspectrometry (LC-MS/MS). PLoS One. 2017 May 12;12(5):e0177615. doi: 10.1371/journal.pone.0177615. eCollection 2017.

Zhang L, Regan DG, Chow EPF, Gambhir M, Cornelisse V, Grulich A, Ong J, Lewis DA, Hocking J, Fairley CK. Neisseria gonorrhoeaeTransmission Among Men Who Have Sex With Men: An Anatomical Site-SpecificMathematical Model Evaluating the Potential Preventive Impact of Mouthwash. Sex Transm Dis. 2017 Oct;44(10):586-592. doi: 10.1097/OLQ.0000000000000661.

Evans LR, Fitzgerald MC, Varma D, Mitra B. A novel approach to improving the interpretation of CT brain in trauma. Injury. 2017 Sep 4. pii: S0020-1383(17)30575-2. doi: 10.1016/j.injury.2017.08.056. [Epub ahead of print]


Ekegren CL, Edwards ER, Page R, Hau R, de Steiger R, Bucknill A, Liew S, Oppy A, Gabbe BJ. Twelve-month mortality and functional outcomes in hip fracture patients under 65 years of age. Injury. 2016 Oct;47(10):2182-2188. doi: 10.1016/j.injury.2016.05.033. Epub 2016 May 26.

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