8-21 June 2021 Central Clinical School recent publications

The need for solid organ transplant for people living with HIV (PLWH)
is increasing as this group, thanks to effective anti-viral treatments, live
longer. A 15 year retrospective audit found donees experienced good
outcomes.

Recent publications featuring research as notified by PubMed during 8-21 June 2021 from Central Clinical School affiliated researchers in the following departments. The below is not a comprehensive list. The most recent validated publications for the school and departments can be seen on their publications pages, linked to from the headings below. Otherwise, read down the entry for recent notifications.

• Anaesthesiology and Perioperative Medicine
• Gastroenterology
• Immunology and Pathology
• Infectious Diseases
• Medicine (including Alfred and Peninsula)
• Melbourne Sexual Health Centre
• Psychiatry
• Neuroscience
• Psychiatry
  
• Surgery (including National Trauma Research Institute)

Australian Centre for Blood Diseases

Boyle S, Wellard C, Moore EM, Blacklock H, Harrison SJ, Ho PJ, Hocking J, McQuilten ZK, Quach H, Spearing R, Wood EM, Spencer A, Mollee P; Myeloma and Related Diseases Registry Investigators. Receiving four or fewer cycles of therapy predicts poor survival in newly diagnosed transplant ineligible patients with myeloma who are treated with bortezomib-based induction. Eur J Haematol. 2021 Jun 15. doi: 10.1111/ejh.13677. Epub ahead of print. PMID: 34129711.
https://pubmed.ncbi.nlm.nih.gov/34129711/

Hocking J, Chunilal SD, Chen VM, Brighton T, Nguyen J, Tan J, Ting SB, Tran H. The first known case of vaccine-induced thrombotic thrombocytopenia in Australia. Med J Aust. 2021 Jun 11. doi: 10.5694/mja2.51135. Epub ahead of print. PMID: 34117641.
https://pubmed.ncbi.nlm.nih.gov/34117641/

Hogg SJ, Motorna O, Cluse LA, ..., Khong T, Spencer A, ..., Johnstone RW. Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition. Mol Cell. 2021 May 20;81(10):2183-2200.e13. doi: 10.1016/j.molcel.2021.04.015. PMID: 34019788; PMCID: PMC8183601.
https://pubmed.ncbi.nlm.nih.gov/34019788/

Medcalf RL, Keragala CB. The Fibrinolytic System: Mysteries and Opportunities. Hemasphere. 2021 Jun 1;5(6):e570. doi: 10.1097/HS9.0000000000000570. PMID: 34095754; PMCID: PMC8171360.
https://pubmed.ncbi.nlm.nih.gov/34095754/

Wang X, Chen M, Dai L, ..., Chen L. Potential biomarkers for inherited thrombocytopenia 2 identified by plasma proteomics. Platelets. 2021 Jun 8:1-8. doi: 10.1080/09537104.2021.1937594. Epub ahead of print. PMID: 34101524.
https://pubmed.ncbi.nlm.nih.gov/34101524/


Department of Diabetes

de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C, Guiry PJ. Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms). J Med Chem. 2021 Jun 17. doi: 10.1021/acs.jmedchem.1c00403. Epub ahead of print. PMID: 34138563.
https://pubmed.ncbi.nlm.nih.gov/34138563/

Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P. Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun. 2021 May 17;12(1):2887. doi: 10.1038/s41467-021-23240-7. PMID: 34001905; PMCID: PMC8129430.
https://pubmed.ncbi.nlm.nih.gov/34001905/


Department of Gastroenterology

Lubel JS, Roberts SK, Strasser SI, Thompson AJ, Philip J, Goodwin M, Clarke S, Crawford DH, Levy MT, Shackel N. Australian recommendations for the management of hepatocellular carcinoma: a consensus statement. Med J Aust. 2021 Jun;214(10):475-483. doi: 10.5694/mja2.50885. Epub 2020 Dec 13. PMID: 33314233.
https://pubmed.ncbi.nlm.nih.gov/33314233/


Departments of Immunology and Pathology; Respiratory Research@Alfred

Bousquet J, Pfaar O, Agache I, ..., O'Hehir RE, ... [many], Jutel M. ARIA-EAACI care pathways for allergen immunotherapy in respiratory allergy. Clin Transl Allergy. 2021 Jun 9;11(4):e12014. doi: 10.1002/clt2.12014. PMID: 34136127; PMCID: PMC8190541.
https://pubmed.ncbi.nlm.nih.gov/34136127/

Hensen L, Illing PT, Bridie Clemens E, Nguyen THO, Koutsakos M, van de Sandt CE, Mifsud NA, Nguyen AT, Szeto C, Chua BY, Halim H, Rizzetto S, Luciani F, Loh L, Grant EJ, Saunders PM, Brooks AG, Rockman S, Kotsimbos TC, Cheng AC, Richards M, Westall GP, Wakim LM, Loudovaris T, Mannering SI, Elliott M, Tangye SG, Jackson DC, Flanagan KL, Rossjohn J, Gras S, Davies J, Miller A, Tong SYC, Purcell AW, Kedzierska K. CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph. Nat Commun. 2021 May 18;12(1):2931. doi: 10.1038/s41467-021-23212-x. PMID: 34006841; PMCID: PMC8132304.
https://pubmed.ncbi.nlm.nih.gov/34006841/

Looman KIM, Santos S, Moll HA, Leijten CWE, Grosserichter-Wagener C, Voortman T, Jaddoe VVW, van Zelm MC, Kiefte-de Jong JC. Childhood adiposity associated with expanded effector memory CD8 + and Vδ2 +Vγ9 + T cells. J Clin Endocrinol Metab. 2021 Jun 15:dgab433. doi: 10.1210/clinem/dgab433. Epub ahead of print. PMID: 34128988.
https://pubmed.ncbi.nlm.nih.gov/34128988/


Department of Infectious Diseases

Dharan NJ, Yeh P, Bloch M, Yeung MM, Baker D, Guinto J, Roth N, Ftouni S, Ognenovska K, Smith D, Hoy JF, Woolley I, Pell C, Templeton DJ, Fraser N, Rose N, Hutchinson J, Petoumenos K, Dawson SJ, Polizzotto MN, Dawson MA; ARCHIVE Study Group. HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults. Nat Med. 2021 Jun;27(6):1006-1011. doi: 10.1038/s41591-021-01357-y. Epub 2021 Jun 7. PMID: 34099923.
https://pubmed.ncbi.nlm.nih.gov/34099923/

Gray J, Prestage G, Jin F, Phanuphak N, Friedman RK, Fairley CK, Kelleher A, Templeton D, Zablotska-Manos I, Hoy J, McNulty A, Pell C, Grulich A, Bavinton B; Opposites Attract Study Group. Characteristics of Agreements to have Condomless Anal Intercourse in the Presence of an Undetectable Viral Load Among HIV Serodiscordant Male Couples in Australia, Brazil and Thailand. AIDS Behav. 2021 Jun 9. doi: 10.1007/s10461-021-03324-7. Epub ahead of print. PMID: 34109529.
https://pubmed.ncbi.nlm.nih.gov/34109529/

Griffin D, Kotecha S, Basu G, Gow P, Lau J, Morrissey CO, Hoy JF. HIV and Solid Organ Transplantation: A 15-Year Retrospective Audit at a Tertiary Australian Transplant Centre. Intern Med J. 2021 Jun 17. doi: 10.1111/imj.15423. Epub ahead of print. PMID: 34139100.
https://pubmed.ncbi.nlm.nih.gov/34139100/

Karanfilovska D, Cheng AC, Spelman D, Worth LJ. Development and Piloting of a Prevention Assessment and Response Tool for Healthcare-Associated Staphylococcus aureus Bloodstream Infection (the SAB-PART Study) Using a Delphi Method. J Hosp Infect. 2021 Jun 11:S0195-6701(21)00223-1. doi: 10.1016/j.jhin.2021.06.001. Epub ahead of print. PMID: 34126103.
https://pubmed.ncbi.nlm.nih.gov/34126103/

Zang M, MacDermott-Opeskin H, Adams FG, ..., Peleg AY, Köper I, Paulsen IT, Hassan KA, O'Mara ML, Eijkelkamp BA. The Membrane Composition Defines the Spatial Organization and Function of a Major Acinetobacter baumannii Drug Efflux System. mBio. 2021 Jun 17:e0107021. doi: 10.1128/mBio.01070-21. Epub ahead of print. PMID: 34134514.
https://pubmed.ncbi.nlm.nih.gov/34134514/


Department of Medicine

Callisaya ML, Jayakody O, Vaidya A, Srikanth V, Farrow M, Delbaere K. A novel cognitive-motor exercise program delivered via a tablet to improve mobility in older people with cognitive impairment - StandingTall Cognition and Mobility. Exp Gerontol. 2021 Jun 8;152:111434. doi: 10.1016/j.exger.2021.111434. Epub ahead of print. PMID: 34098009.
https://pubmed.ncbi.nlm.nih.gov/34098009/

Callisaya ML, Lee AH, Khushu A. Rapid implementation of telehealth in geriatric outpatient clinics due to COVID-19. Intern Med J. 2021 Jun 18. doi: 10.1111/imj.15306. Epub ahead of print. PMID: 34143563.
https://pubmed.ncbi.nlm.nih.gov/34143563/

Kilkenny MF, Phan HT, Lindley RI, Kim J, Lopez D, Dalli LL, Grimley R, Sundararajan V, Thrift AG, Andrew NE, Donnan GA, Cadilhac DA; Stroke123 Investigators and the AuSCR Consortium. Utility of the Hospital Frailty Risk Score Derived From Administrative Data and the Association With Stroke Outcomes. Stroke. 2021 Jun 17:STROKEAHA120033648. doi: 10.1161/STROKEAHA.120.033648. Epub ahead of print. PMID: 34134509.
https://pubmed.ncbi.nlm.nih.gov/34134509/


Melbourne Sexual Health Centre

Chow EPF, Fairley CK. Is it the end of mouthwash as an intervention for gonorrhoea? Lancet Infect Dis. 2021 Jun;21(6):763-764. doi: 10.1016/S1473-3099(21)00195-X. PMID: 34051184.
https://pubmed.ncbi.nlm.nih.gov/34051184/

Jiang H, Xie Y, Xiong Y, Zhou Y, Lin K, Yan Y, Tucker J, Ong JJ, Wu D, Yang F, Tang W. HIV self-testing partially filled the HIV testing gap among men who have sex with men in China during the COVID-19 pandemic: results from an online survey. J Int AIDS Soc. 2021 May;24(5):e25737. doi: 10.1002/jia2.25737. PMID: 34036750; PMCID: PMC8150052.
https://pubmed.ncbi.nlm.nih.gov/34036750/

Tahlil KM, Obiezu-Umeh C, Gbajabiamila T, ..., Ong JJ, Conserve DF, Iwelunmor J, Ezechi O, Tucker JD. A designathon to co-create community-driven HIV self-testing services for Nigerian youth: findings from a participatory event. BMC Infect Dis. 2021 May 31;21(1):505. doi: 10.1186/s12879-021-06212-6. PMID: 34059014; PMCID: PMC8166032.
https://pubmed.ncbi.nlm.nih.gov/34059014/

Wang Y, Zhang W, Bao D, Ong JJ, Tucker JD, Ye R, Zheng H, Yang B, Wang C. Social network distribution of syphilis self-testing among men who have sex with men in China: study protocol for a cluster randomized control trial. BMC Infect Dis. 2021 May 27;21(1):491. doi: 10.1186/s12879-021-06137-0. PMID: 34044760; PMCID: PMC8161568.
https://pubmed.ncbi.nlm.nih.gov/34044760/


Department of Neuroscience

Andersen JB, Sharmin S, Lefort M, ..., Butzkueven H, Kalincik T, Vukusic S, Magyari M. The effectiveness of natalizumab vs fingolimod-A comparison of international registry studies. Mult Scler Relat Disord. 2021 May 8;53:103012. doi: 10.1016/j.msard.2021.103012. Epub ahead of print. PMID: 34116480.
https://pubmed.ncbi.nlm.nih.gov/34116480/

Boonstra FM, Noffs G, Perera T, Jokubaitis VG, Vogel AP, Moffat BA, Butzkueven H, Evans A, van der Walt A, Kolbe SC. Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis. Mult Scler. 2020 May;26(6):696-705. doi: 10.1177/1352458519837706. Epub 2019 Mar 25. PMID: 30907236.
https://pubmed.ncbi.nlm.nih.gov/30907236/

Dalton EJ, Churilov L, Lannin NA, Corbett D, Campbell BCV, Hayward KS. Multidimensional Phase I Dose Ranging Trials for Stroke Recovery Interventions: Key Challenges and How to Address Them. Neurorehabil Neural Repair. 2021 Jun 4:15459683211019362. doi: 10.1177/15459683211019362. Epub ahead of print. PMID: 34085851. https://pubmed.ncbi.nlm.nih.gov/34085851/

See feature story; ran in
Herald Sun 22 June.

Major B, Symons GF, Sinclair B, O'Brien WT, Costello D, Wright DK, Clough M, Mutimer S, 0, Yamakawa GR, Brady RD, O'Sullivan MJ, Mychasiuk R, McDonald SJ, O'Brien TJ, Law M, Kolbe S, Shultz SR. White and Gray Matter Abnormalities in Australian Footballers With a History of Sports-Related Concussion: An MRI Study. Cereb Cortex. 2021 Jun 19:bhab161. doi: 10.1093/cercor/bhab161. Epub ahead of print. PMID: 34148076.
https://pubmed.ncbi.nlm.nih.gov/34148076/

See CAA feature story

Mutimer CA, Keragala CB, Markus HS, Werring DJ, Cloud GC, Medcalf RL. Cerebral Amyloid Angiopathy and the Fibrinolytic System: Is Plasmin a Therapeutic Target? Stroke. 2021 Jun 15:STROKEAHA120033107. doi: 10.1161/STROKEAHA.120.033107. Epub ahead of print. PMID: 34126761.
https://pubmed.ncbi.nlm.nih.gov/34126761/

Nicolo JP, Moffat B, Wright DK, Sinclair B, Neal A, Lui E, Desmond P, Glarin R, Davis KA, Reddy R, Yan B, O'Brien TJ, Kwan P. 7T Magnetic Resonance Imaging Quantification of Brain Glutamate in Acute Ischaemic Stroke. J Stroke. 2021 May;23(2):281-284. doi: 10.5853/jos.2020.04784. Epub 2021 May 31. PMID: 34102764; PMCID: PMC8189859.
https://pubmed.ncbi.nlm.nih.gov/34102764/

Opie NL, O'Brien TJ. The Potential of Closed-Loop Endovascular Neurostimulation as a Viable Therapeutic Approach for Drug Resistant Epilepsy: A Critical Review. Artif Organs. 2021 Jun 8. doi: 10.1111/aor.14007. Epub ahead of print. PMID: 34101849.
https://pubmed.ncbi.nlm.nih.gov/34101849/

Reyes S, Cunningham AL, Kalincik T, ..., van der Walt A, Oh J, Mathews J, Mateen FJ, Giovannoni G. Update on the management of multiple sclerosis during the COVID-19 pandemic and post pandemic: An international consensus statement. J Neuroimmunol. 2021 Jun 7;357:577627. doi: 10.1016/j.jneuroim.2021.577627. Epub ahead of print. PMID: 34139567; PMCID: PMC8183006.
https://pubmed.ncbi.nlm.nih.gov/34139567/

Shi YW, Wang J, Min FL,... Kwan P, Liao WP. HLA Risk Alleles in Aromatic Antiepileptic Drug-Induced Maculopapular Exanthema. Front Pharmacol. 2021 May 26;12:671572. doi: 10.3389/fphar.2021.671572. PMID: 34122097; PMCID: PMC8187898.
https://pubmed.ncbi.nlm.nih.gov/34122097/

Storey E, Bui MQ, Stimpson P, Tassone F, Atkinson A, Loesch DZ. Relationships between motor scores and cognitive functioning in FMR1 female premutation X carriers indicate early involvement of cerebello-cerebral pathways. Cerebellum Ataxias. 2021 Jun 11;8(1):15. doi: 10.1186/s40673-021-00138-0. PMID: 34116720; PMCID: PMC8196444.
https://pubmed.ncbi.nlm.nih.gov/34116720/

See feature story

Strik M, Cofré Lizama LE, Shanahan CJ, van der Walt A, Boonstra FMC, Glarin R, Kilpatrick TJ, Geurts JJG, Cleary JO, Schoonheim MM, Galea MP, Kolbe SC. Axonal loss in major sensorimotor tracts is associated with impaired motor performance in minimally disabled multiple sclerosis patients. Brain Communications, Volume 3, Issue 2, 2021, fcab032,https://doi.org/10.1093/braincomms/fcab032

 

Department of Psychiatry

Beilharz F, Sukunesan S, Rossell SL, Kulkarni J, Sharp G. Development of a Positive Body Image Chatbot (KIT) With Young People and Parents/Carers: Qualitative Focus Group Study. J Med Internet Res. 2021 Jun 16;23(6):e27807. doi: 10.2196/27807. PMID: 34132644.
https://pubmed.ncbi.nlm.nih.gov/34132644/

Filia KM, Cotton SM, Watson AE, Jayasinghe A, Kerr M, Fitzgerald PB. Understanding the Barriers and Facilitators to Employment for People with Bipolar Disorder. Psychiatr Q. 2021 Jun 7. doi: 10.1007/s11126-021-09931-w. Epub ahead of print. PMID: 34097245.
https://pubmed.ncbi.nlm.nih.gov/34097245/

Grewal JK, Kulkarni J. Complex post-traumatic stress disorder and pre-menstrual dysphoric disorder. Aust N Z J Psychiatry. 2021 Jun 17:48674211025627. doi: 10.1177/00048674211025627. Epub ahead of print. PMID: 34134539.
https://pubmed.ncbi.nlm.nih.gov/34134539/

Pikoos TD, Buzwell S, Sharp G, Rossell SL. The Zoom Effect: Exploring the Impact of Video Calling on Appearance Dissatisfaction and Interest in Aesthetic Treatment During the COVID-19 Pandemic. Aesthet Surg J. 2021 Jun 19:sjab257. doi: 10.1093/asj/sjab257. Epub ahead of print. PMID: 34146086.
https://pubmed.ncbi.nlm.nih.gov/34146086/


Department of Surgery

Choo N, Ramm S, Luu J, ..., Frydenberg M, Grummet J, ..., Simpson KJ. High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids. SLAS Discov. 2021 Jun 11:24725552211020668. doi: 10.1177/24725552211020668. Epub ahead of print. PMID: 34111999.
https://pubmed.ncbi.nlm.nih.gov/34111999/

Moris L, Gandaglia G, Vilaseca A, ..., Grummet JP, ..., Mottet N. Evaluation of Oncological Outcomes and Data Quality in Studies Assessing Nerve-sparing Versus Non-Nerve-sparing Radical Prostatectomy in Nonmetastatic Prostate Cancer: A Systematic Review. Eur Urol Focus. 2021 Jun 16:S2405-4569(21)00161-9. doi: 10.1016/j.euf.2021.05.009. Epub ahead of print. PMID: 34147405.
https://pubmed.ncbi.nlm.nih.gov/34147405/