Hattapark's thesis is titled "The Role of Glutamate in the Pathogenesis of Acquired Epilepsy in Alzheimer's Disease". He was supervised by Professor Patrick Kwan and Associate Professor Nigel Jones, both in Department of Neuroscience at CCS.
He writes, "Alzheimer’s disease (AD) patients have up to 10-fold higher risk of developing epilepsy compared to healthy controls. However, the mechanism that links AD pathologies to epileptic seizures is not elucidated. We do know that disruption to glutamate-glutamine cycle in the brain caused by AD has the potential to enhance this risk.
"I found that the amount of key components in the glutamate-glutamine cycle, such as GLT-1, were altered in the seizure-prone mouse model of AD. Also, pharmacologically enhancing GLT-1 level reduced the seizure severity in the same model. Thus, disruption to glutamate-glutamine cycle can be one of the links between AD and epilepsy."
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