22 May 2019

Broccoli! The bitter brassica delivering a sweet health reward

by Anne Crawford

Broccoli, love it or hate it, is well-known as a food that has a host of vitamins, minerals and fibre beneficial to our health in general. Evidence is mounting too that it may have properties to help fight cancer, boost immunity, counter inflammation and even help children with autism.

A team led by Dr Tom Karagiannis from Monash University’s Department of Diabetes has published a review of clinical trials worldwide testing the benefits of the active ingredient sulforaphane. Sulforaphane is produced in the body from a naturally occurring compound called glucoraphanin, found in cruciferous vegetables including cauliflower, cabbage, bok choy and broccoli. The highest concentration is found in broccoli sprouts.

“We looked at more than 100 clinical trials done into sulforaphane and how effective it was in different types of disease,” Dr Karagiannis said. “In the last couple of years, research has increased exponentially on this compound,” he said.

The review, published in Clinical Nutrition last month, is part of a body of work by Dr Karagiannis with the ultimate aim of developing a pharmaceutical-grade sulforaphane preparation for clinical use in inflammatory conditions.


CCS Recent Publications: 3rd May - 19th May

Prof. Paul Zimmet's article calling for recognition
of a new syndrome has been published this month.
Recent publications for Central Clinical School feature affiliated authors in the following departments:

  • Melbourne Sexual Health Centre
  • Neuroscience
  • MAPrc
  • AIRMed
  • NTRI
  • Anaesthesia and Perioperative Medicine
  • Peninsula Clinical School
  • Obesity Research and Education
  • Diabetes
  • Surgery
  • Gastroenterology
  • ACBD



Translational Research Symposium Speaker Spotlight: Associate Professor Kathryn Holt


PLEAA/Prof Kathryn Holt
UPDATE: A/Prof Kat Holt will no longer be speaking at the symposium.  Dr Kelly Wyres will be speaking instead.

Monash University's 5th annual Translational Research Symposium is being hosted by its three metropolitan clinical schools on 21 June 2019. The symposium will host a diverse group of medical researchers presenting their work into translational research. RSVP here.

Associate Professor Kathryn Holt is a group leader in the Department of Infectious Diseases at Central Clinical School and Alfred Health.

15 May 2019

CCS Recent Publications: 30th April - 6th May

Due to staff illness, this week's recent publications will be included in the next edition of the CCS News.

Revealing the mysterious ways the gut affects kidney disease

by Anne Crawford
Dr Matthew Snelson

Chronic Kidney Disease (CKD) is estimated to affect 13 per cent of the population globally. It is associated with a two- to three-fold increased risk of death caused by the disease itself and also carries a higher risk to patients of dying from heart disease or stroke.

Patients with CKD have increased levels of uremic toxins – toxins produced by bacteria in the gut that are normally excreted in the urine in healthy people but which build up in those with CKD.

A recent PhD graduate of Monash University’s Central Clinical School has conducted a review of literature to understand how this happens as a base to eventually finding ways of preventing it by creating new therapeutics.

Dr Matthew Snelson, a winner of the CCS’s 3MT (three minute thesis) award, became interested in CKD as a clinical dietitian working in Perth. “I was very interested in the role of gut microbiota and the mechanisms by which diet affects disease outcomes,” he said. “The emerging evidence looking at the link between the gut and the kidney was a really interesting area.”


Study reveals new mechanism of gonorrhoea transmission


A/Prof Eric Chow from the Melbourne Sexual Health Centre was in the Washington Post recently following publication of a paper on which he was lead author. The paper, published in Sexually Transmitted Infections, found that kissing with tongue may be a way to transmit oropharyngeal gonorrhoea, or oral gonorrhoea, particularly among gay and bisexual men. The study team featured a number of other Central Clinical School researchers.

CCS Travel Grant Outcome - 2019 Round 1

CCS is pleased to announce the successful recipients of the 2019 Round 1 Travel Grant. Congratulations to all.

For information and guidelines on the scheme, visit https://sites.google.com/a/monash.edu/ccsintranet/research/funding/opportunities
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