Department of Immunology researcher, Prof Magdalena Plebanski has been awarded an ARC Discovery Grant for her research in biodegradable nanoparticles. Prof Plebanski is the project's lead investigator along with A/Prof Cordelia Selomulya from the Department of Chemical Engineering.
This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluidic drying approach. The potential applications of iNPs are wide-ranging and are not restricted to pulmonary targeting. The potential commercial implications for Australia's emerging biopharmaceutical industry are substantial.
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