Developing prognostics for post-TBI

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When the brain experiences traumatic injury (TBI), a number of pathways are activated, contributing to what is known as 'excitotoxicity'. This paper investigates how TBI stimulates the kynurenine pathway, contributing to neurotoxicity, and therefore the possibility of its measurement for prognostic use.

Reference: Yan EB, Frugier T, Lim CK, Heng B, Sundaram G, Tan M, Rosenfeld JV, Walker DW, Guillemin GJ, Morganti-Kossmann MC. Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans. Journal of Neuroinflammation (2015) 12:110 doi:10.1186/s12974-015-0328-2