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To assess the genetic factors contributing to daptomycin resistance in Staphylococcus aureus, the draft genome of a clinically derived daptomycin-nonsusceptible isolate APS211 was generated and compared to the draft sequence of its susceptible progenitor strain APS210. Four genetic differences were identified including a previously described mutation within the mprF gene.
Reference: Cameron DR, Jiang J-H, Abbott IJ, Spelman DW, Peleg AY. 2015. Draft genome sequences of clinical daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus strain APS211 and its daptomycin-susceptible progenitor APS210. Genome Announc 3(3):e00568-15. doi:10.1128/genomeA.00568-15
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