|ACBD research group working on leukaemia stem cells. L-R: Ms Loretta Cerruti, A/Prof Stephen Ting, Ms Jacqueline Boyle, A/Prof David Curtis, Dr Cedric Tremblay, Dr Stefan Sonderegger, Dr Emma Toulmin, Dr Christina Tebartz, Ms Jesslyn Saw, Mr Andrej Terzic, Ms Michelle Karlik, Ms Ashlee Conway. The bolded names are co-authors on a recent paper investigating pre-leukaemia stem cell mutations. |
Cure rates for acute leukemia have not improved over the last 20 years. One explanation for this lack of progress is the existence of rare leukemic cells that escape chemotherapy. Using genetically modified mice that can track cells according to their cycling kinetics, we found that dormant leukemic cells are essential for the progression of the disease. Most importantly, we show that these dormant cells escape chemotherapy and lead to recurrence of the disease in acute leukemia. This work will identify new ways to eliminate these therapy-resistant cells and improve cure rates for patients with acute leukemia.
Besford QA, Ju Y1, Wang TY, Yun G, Cherepanov P, Hagemeyer CE, Cavalieri F, Caruso F. Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles. Small. 2018 Aug 29:e1802342. doi: 10.1002/smll.201802342. [Epub ahead of print]
Tremblay CS, Saw J, Chiu SK, Wong NC, Tsyganov K, Ghotb S, Graham AN, Yan F, Guirguis AA, Sonderegger SE, Lee N, Kalitsis P, Reynolds J, Ting SB, Powell DR, Jane SM, Curtis DJ. Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells. Nat Commun. 2018 Aug 30;9(1):3535. doi: 10.1038/s41467-018-06021-7.
Pallin M, Keating D, Kaye DM, Kotsimbos T, Wilson JW. Subclinical Left Ventricular Dysfunction is Influenced by Genotype Severity in Patients with Cystic Fibrosis. Clin Med Insights Circ Respir Pulm Med. 2018 Aug 19;12:1179548418794154. doi: 10.1177/1179548418794154. eCollection 2018.
Jha JC, Ho F, Dan C, Jandeleit-Dahm K. A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes. Clin Sci (Lond). 2018 Aug 30;132(16):1811-1836. doi: 10.1042/CS20171459. Print 2018 Aug 31.
Williams E, Lew TE, Fuller A, Spelman DW , Jenney AW. A case of multi-drug resistant ESBL-producing Shigella sonnei acute acalculous cholecystitis and gastroenteritis in a returned traveller. J Travel Med. 2018 Aug 1;25(1). doi: 10.1093/jtm/tay029.
Trevillyan JM, Wong G, Puls R, Petoumenos K, Emery S, Mellett NA, Mundra PA, Meikle PJ, Hoy JF, ALTAIR Study Group. Changes in plasma lipidome following initiation of antiretroviral therapy. PLoS One. 2018 Aug 29;13(8):e0202944. doi: 10.1371/journal.pone.0202944. eCollection 2018.
Guérillot R, Li L, Baines S, Howden B, Schultz MB, Seemann T, Monk I, Pidot SJ, Gao W, Giulieri S, Gonçalves da Silva A, D'Agata A, Tomita T, Peleg AY, Stinear TP, Howden BP. Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq). Genome Med. 2018 Aug 31;10(1):63. doi: 10.1186/s13073-018-0572-z.
Monash Alfred Psychiatry research centre (MAPRC)
Gurvich C, Hoy K, Thomas N, Kulkarni J. Sex Differences and the Influence of Sex Hormones on Cognition through Adulthood and the Aging Process. Brain Sci. 2018 Aug 28;8(9). pii: E163. doi: 10.3390/brainsci8090163.
Bailey NW, Hoy KE, Rogasch NC, Thomson RH, McQueen S, Elliot D, Sullivan CM, Fulcher BD, Daskalakis ZJ, Fitzgerald PB. Differentiating responders and non-responders to rTMS treatment for depression after one week using resting EEG connectivity measures. J Affect Disord. 2018 Aug 14;242:68-79. doi: 10.1016/j.jad.2018.08.058. [Epub ahead of print]
Carruthers SP, Gurvich CT, Cropley VL, Pantelis C, Bousman C, Lenroot RK, Bruggemann JM, Weickert T, Australian Schizophrenia Research Bank, Rossell SL. The effects of a muscarinic receptor 1 gene variant on cortical thickness and surface area in schizophrenia. Psychiatry Res Neuroimaging. 2018 Aug 24;280:62-64. doi: 10.1016/j.pscychresns.2018.08.014. [Epub ahead of print]
Loesch DZ, Tassone F, Mellick GD, Horne M, Rubio JP, Bui MQ, Francis D, Storey E. Evidence for the role of FMR1 gray zone alleles as a risk factor for parkinsonism in females. Mov Disord. 2018 Jul;33(7):1178-1181. doi: 10.1002/mds.27420.
Melbourne Sexual Health Centre
Chow EPF, Medland NA, Denham I, Wright EJ, Fairley CK. Decline in new HIV diagnoses among MSM in Melbourne. The Lancet HIV. 2018; 5(9): E479-E481.
National Trauma Research Institute
Olaussen A , Bade-Boon J, Fitzgerald MC, Mitra B. Management of injured patients who were Jehovah's Witnesses, where blood transfusion may not be an option: a retrospective review. Vox Sang. 2018 Apr;113(3):283-289. doi: 10.1111/vox.12637. Epub 2018 Feb 2.
Maher DI, Williams E, Grodski S, Serpell JW, Lee JC. Adrenal incidentaloma follow-up is influenced by patient, radiologic, and medical provider factors: A review of 804 cases. Surgery. 2018 Aug 28. pii: S0039-6060(18)30456-2. doi: 10.1016/j.surg.2018.07.011. [Epub ahead of print]