16-22 March 2021 Central Clinical School recent publications

Semple group L-R: Rishabh Sharma, Dr Akram Zamani, Erskine Chu,
Dr Bridgette Semple, Laken Willis, Larissa Dill. With the exception of
Laken, all are co-authors on a new study looking at paediatric TBI and
infection. Rishabh Sharma is first author and Bridgette's PhD student.
The group asks how bad are TBI and infection together? We don't yet know.

Recent publications featuring research as notified by PubMed during 16-22 March 2021 from Central Clinical School affiliated researchers in the following departments. The below is not a comprehensive list. Most recent validated publications for the school and departments can be seen on their publications pages, linked to from the headings below. Otherwise, read down the entry for recent notifications.

• Anaesthesia and Perioperative Medicine
• Gastroenterology
• Immunology and Pathology
• Infectious Diseases
• Medicine (including AIRmed)
• Melbourne Sexual Health Centre
• Monash Alfred Psychiatry research centre
• Neuroscience
• Peninsula Clinical School
• Psychiatry
  
• Surgery (including National Trauma Research Institute)

 Department of Allergy, Immunology and Respiratory Medicine

Pfaar O, Klimek L, Jutel M, ..., O'Hehir RE, ..., Agache I. COVID-19 pandemic: Practical considerations on the organization of an allergy clinic-An EAACI/ARIA Position Paper. Allergy. 2021 Mar;76(3):648-676. doi: 10.1111/all.14453. PMID: 32531110; PMCID: PMC7323448.
https://pubmed.ncbi.nlm.nih.gov/32531110/

Rowntree LC, van den Heuvel H, Sun J, D'Orsogna LJ, Nguyen THO, Claas FHJ, Rossjohn J, Kotsimbos TC, Purcell AW, Mifsud NA. Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors. Front Immunol. 2020 Feb 19;11:248. doi: 10.3389/fimmu.2020.00248. PMID: 32140156; PMCID: PMC7042382.
https://pubmed.ncbi.nlm.nih.gov/32140156/


Department of Anaesthesiology and Perioperative Medicine

Mitra B, Bernard S, Gantner D, Burns B, Reade MC, Murray L, Trapani T, Pitt V, McArthur C, Forbes A, Maegele M, Gruen RL; PATCH-Trauma study investigators; PATCH-Trauma Study investigators. Protocol for a multicentre prehospital randomised controlled trial investigating tranexamic acid in severe trauma: the PATCH-Trauma trial. BMJ Open. 2021 Mar 15;11(3):e046522. doi: 10.1136/bmjopen-2020-046522. PMID: 33722875.
https://pubmed.ncbi.nlm.nih.gov/33722875/


Australian Centre for Blood Diseases

Keragala CB, Medcalf RL. Plasminogen: an enigmatic zymogen. Blood. 2021 Mar 18:blood.2020008951. doi: 10.1182/blood.2020008951. Epub ahead of print. PMID: 33735914.
https://pubmed.ncbi.nlm.nih.gov/33735914/


Department of Diabetes

Lunke S, Maxwell S, Khurana I, Harikrishnan KN, Okabe J, Al-Hasani K, El-Osta A. Epigenetic evidence of an Ac/Dc axis by VPA and SAHA. Clin Epigenetics. 2021 Mar 20;13(1):58. doi: 10.1186/s13148-021-01050-4. PMID: 33743782.
https://pubmed.ncbi.nlm.nih.gov/33743782/

Pitsillou E, Liang J, Hung A, Karagiannis TC. Inhibition of interferon-stimulated gene 15 and lysine 48-linked ubiquitin binding to the SARS-CoV-2 papain-like protease by small molecules: In silico studies. Chem Phys Lett. 2021 May 16;771:138468. doi: 10.1016/j.cplett.2021.138468. Epub 2021 Mar 8. PMID: 33716308; PMCID: PMC7938750.
https://pubmed.ncbi.nlm.nih.gov/33716308/

Pitsillou E, Liang J, Ververis K, Hung A, Karagiannis TC. Interaction of small molecules with the SARS-CoV-2 papain-like protease: In silico studies and in vitro validation of protease activity inhibition using an enzymatic inhibition assay. J Mol Graph Model. 2021 May;104:107851. doi: 10.1016/j.jmgm.2021.107851. Epub 2021 Jan 26. PMID: 33556646; PMCID: PMC7837617.
https://pubmed.ncbi.nlm.nih.gov/33556646/


Department of Infectious Diseases

Blyth CC, Flanagan KL, Gibbs RA, Crawford NW, Cheng AC. Key steps in our journey to a COVID-19 vaccine program. Med J Aust. 2021 Mar 21. doi: 10.5694/mja2.50978. Epub ahead of print. PMID: 33745153.
https://pubmed.ncbi.nlm.nih.gov/33745153/

Wade AJ, Doyle JS, Draper B, Howell J, Iser D, Roberts SK, Kemp W, Thompson AJ, Hellard ME. In support of community-based hepatitis C treatment with triage of people at risk of cirrhosis to specialist care. J Viral Hepat. 2021 Jan;28(1):217-218. doi: 10.1111/jvh.13391. PMID: 32860312.
https://pubmed.ncbi.nlm.nih.gov/32860312/

 

Department of Medicine - Alfred and Peninsula

Best JG, Ambler G, Wilson D,..., Karayiannis C, ..., Srikanth V, ...,Werring DJ; Microbleeds International Collaborative Network. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurol. 2021 Apr;20(4):294-303. doi: 10.1016/S1474-4422(21)00024-7. Epub 2021 Mar 17. PMID: 33743239.
https://pubmed.ncbi.nlm.nih.gov/33743239/

de Jong AU, Smith M, Callisaya ML, Schmidt M, Simpson DB. Sedentary time and physical activity patterns of stroke survivors during the inpatient rehabilitation week. Int J Rehabil Res. 2021 Mar 12. doi: 10.1097/MRR.0000000000000461. Epub ahead of print. PMID: 33724969.
https://pubmed.ncbi.nlm.nih.gov/33724969/

Nasa P, Azoulay E, Khanna ..., Tiruvoipati R, ... Myatra SN. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Crit Care. 2021 Mar 16;25(1):106. doi: 10.1186/s13054-021-03491-y. PMID: 33726819; PMCID: PMC7962430.
https://pubmed.ncbi.nlm.nih.gov/33726819/

Thayabaranathan T, Andrew NE, Stolwyk R, Lannin NA, Cadilhac DA. Comparing the EQ-5D-3L anxiety or depression domain to the Hospital Anxiety and Depression Scale to identify anxiety or depression after stroke. Top Stroke Rehabil. 2021 Mar 17:1-10. doi: 10.1080/10749357.2021.1895494. Epub ahead of print. PMID: 33726636.
https://pubmed.ncbi.nlm.nih.gov/33726636/

Vergara IA, Mintoff CP, Sandhu S, ..., Papenfuss AT, Shackleton M. Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling. Nat Commun. 2021 Mar 4;12(1):1434. doi: 10.1038/s41467-021-21576-8. PMID: 33664264; PMCID: PMC7933255.
https://pubmed.ncbi.nlm.nih.gov/33664264/


Department of Neuroscience

Butzkueven H, Spelman T, Horakova D, ..., Wolinsky JS. Risk of requiring a wheelchair in primary progressive multiple sclerosis: Data from the ORATORIO trial and the MSBase registry. Eur J Neurol. 2021 Mar 16. doi: 10.1111/ene.14824. Epub ahead of print. PMID: 33724638.
https://pubmed.ncbi.nlm.nih.gov/33724638/

Cadilhac DA, Kim J, Tod EK, ..., Cloud GC, ..., Lannin NA, ..., Campbell BCV; AuSCR COVID-19 Reporting Consortium Group. COVID-19 Pandemic Impact on Care for Stroke in Australia: Emerging Evidence From the Australian Stroke Clinical Registry. Front Neurol. 2021 Feb 26;12:621495. doi: 10.3389/fneur.2021.621495. PMID: 33716925; PMCID: PMC7952624.
https://pubmed.ncbi.nlm.nih.gov/33716925/

Cruz EM, Miller C, Zhang W, Rogers K, Lee HJ, Wells Y, Cloud G, Lannin NA. EXPRESS: Does Non-Implanted Electrical Stimulation Reduce Post-Stroke Urinary or Fecal Incontinence? A Systematic Review with Meta-Analysis. Int J Stroke. 2021 Mar 16:17474930211006301. doi: 10.1177/17474930211006301. Epub ahead of print. PMID: 33724094.
https://pubmed.ncbi.nlm.nih.gov/33724094/

Drill M, Jones NC, Hunn M, O'Brien TJ, Monif M. Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer. Purinergic Signal. 2021 Mar 17. doi: 10.1007/s11302-021-09776-9. Epub ahead of print. PMID: 33728582.
https://pubmed.ncbi.nlm.nih.gov/33728582/

Gulcebi MI, Bartolini E, Lee O, ..., Foley A; Epilepsy Climate Change Consortium [incl. O'Brien TJ, Perucca P], Sisodiya SM. Climate change and epilepsy: Insights from clinical and basic science studies. Epilepsy Behav. 2021 Mar;116:107791. doi: 10.1016/j.yebeh.2021.107791. Epub 2021 Feb 10. PMID: 33578223.
https://pubmed.ncbi.nlm.nih.gov/33578223/

Holper S, Foster E, Lloyd M, Rayner G, Rychkova M, Ali R, Winton-Brown TT, Velakoulis D, O'Brien TJ, Kwan P, Malpas CB. Clinical predictors of discordance between screening tests and psychiatric assessment for depressive and anxiety disorders among patients being evaluated for seizure disorders. Epilepsia. 2021 Mar 18. doi: 10.1111/epi.16871. Epub ahead of print. PMID: 33735445.
https://pubmed.ncbi.nlm.nih.gov/33735445/

O'Brien WT, Pham L, Brady RD, Bain J, Yamakawa GR, Sun M, Mychasiuk R, O'Brien TJ, Monif M, Shultz SR, McDonald SJ. Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury. Exp Neurol. 2021 Mar 13:113698. doi: 10.1016/j.expneurol.2021.113698. Epub ahead of print. PMID: 33727100.
https://pubmed.ncbi.nlm.nih.gov/33727100/

Sharma R, Zamani A, Dill LK, Sun M, Chu E, Robinson MJ, O'Brien TJ, Shultz SR, Semple BD. A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury. J Neuroinflammation. 2021 Mar 17;18(1):72. doi: 10.1186/s12974-021-02114-1. PMID: 33731173.
https://pubmed.ncbi.nlm.nih.gov/33731173/

Wang Y, Li Z, Zhang X, ..., Kwan P. Development and validation of a clinical score to predict late seizures after intracerebral hemorrhage in Chinese. Epilepsy Res. 2021 Mar 5;172:106600. doi: 10.1016/j.eplepsyres.2021.106600. Epub ahead of print. PMID: 33721707.
https://pubmed.ncbi.nlm.nih.gov/33721707/


Department of Surgery

Kalapara AA, Ballok ZE, Ramdave S, O'Sullivan R, Ryan A, Konety B, Grummet JP, Frydenberg M. Combined Utility of 68Ga-Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography and Multiparametric Magnetic Resonance Imaging in Predicting Prostate Biopsy Pathology. Eur Urol Oncol. 2021 Mar 16:S2588-9311(21)00040-7. doi: 10.1016/j.euo.2021.02.006. Epub ahead of print. PMID: 33741337.
https://pubmed.ncbi.nlm.nih.gov/33741337/