|Dr Nicole Garcia, now a plastic surgery registrar at PeterMac|
Little is known about the mechanism by which skin grafting accelerates wound healing. Dr Garcia writes, "We investigated this using an autologous full-thickness and a synthetic graft in a novel mouse model.Through PCR and protein analysis, it is postulated that the inflammatory stage of wound healing is modulated via the application of grafts. Furthermore, collagen deposition is significantly different between the two grafts. Several key biomolecules may play a key part in the suppression of inflammation and of the altered collagen remodelling. Identification of these biomolecules and elucidation of how grafts repair wounds is key in the formulation of new skin substitutes." See her thesis online in the Monash library.