Professor Jayashri Kulkarni and a team of researchers at the Monash Alfred Psychiatry research centre
have published evidence in the journal Molecular Psychiatry, showing
the clinical effectiveness of estrogen as an adjunct therapy for women
with treatment-resistant schizophrenia. Their large-scale trial adds to
the growing body of evidence that estradiol has antipsychotic effects,
particularly at higher doses, and has a clinically meaningful effect in
this particular group of women. See article reference and abstract.