11 Feb 2021

22 Dec 2020 - 8 Feb 2021 Central Clinical School publications featuring COVID-19 research

B cell memory: Why it's so important for COVID-19 immunity
Review article
from Professor David Tarlinton and Dr Isaak Quast
explains how B cell memory is generated by infection and vaccination,
what influences its efficacy and persistence, and its relevance for
vaccine development.
Recent publications featuring research as notified by PubMed during 22 December 2020 - 8 Feb 2021 from Central Clinical School affiliated researchers in the following departments featuring research on COVID-19. The below is not a comprehensive list:

  • Anaesthesiology and Perioperative Medicine
  • Diabetes 
  • Immunology and Pathology
  • Infectious Diseases
  • Medicine - Alfred & Peninsula
  • Melbourne Sexual Health Centre
  • Surgery

Department of Anaesthesiology and Perioperative Medicine

Coatsworth N, Myles PS, Mann GJ, Cockburn IA, Forbes AB, Gardiner EE, Lum G, Cheng AC, Gruen RL; SARS-CoV-2 Testing in Elective Surgery Collaborators. Prevalence of asymptomatic SARS-CoV-2 infection in elective surgical patients in Australia: a prospective surveillance study. ANZ J Surg. 2021 Jan 9. doi: 10.1111/ans.16564. Epub ahead of print. PMID: 33421257.

Department of Diabetes

Pitsillou E, Liang J, Ververis K, Lim KW, Hung A, Karagiannis TC. Identification of Small Molecule Inhibitors of the Deubiquitinating Activity of the SARS-CoV-2 Papain-Like Protease: in silico Molecular Docking Studies and in vitro Enzymatic Activity Assay. Front Chem. 2020 Dec 8;8:623971. doi: 10.3389/fchem.2020.623971. PMID: 33364229; PMCID: PMC7753156.

Department of Immunology and Pathology

See blog story

Hartley GE, Edwards ESJ, Aui PM, Varese N, Stojanovic S, McMahon J, Peleg AY, Boo I, Drummer HE, Hogarth PM, O'Hehir RE, van Zelm MC. Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence. Sci Immunol. 2020 Dec 22;5(54):eabf8891. doi: 10.1126/sciimmunol.abf8891. PMID: 33443036.

Quast I, Tarlinton D. B cell memory: understanding COVID-19. Immunity. 2021 Jan 23:S1074-7613(21)00037-6. doi: 10.1016/j.immuni.2021.01.014. Epub ahead of print. PMID: 33513337; PMCID: PMC7826135.

A primer on "B cell memory: understanding #COVID19" from Professor David Tarlinton and Dr Isaak Quast explains how B cell memory is generated by infection and vaccination, what influences its efficacy and persistence, and its relevance for vaccine development.

Department of Infectious Diseases

Burrell AJ, Pellegrini B, Salimi F, Begum H, Broadley T, Campbell LT, Cheng AC, Cheung W, Cooper DJ, Earnest A, Erickson SJ, French CJ, Kaldor JM, Litton E, Murthy S, McAllister RE, Nichol AD, Palermo A, Plummer MP, Ramanan M, Reddi BA, Reynolds C, Trapani T, Webb SA, Udy AA. Outcomes for patients with COVID-19 admitted to Australian intensive care units during the first four months of the pandemic. Med J Aust. 2021 Jan;214(1):23-30. doi: 10.5694/mja2.50883. Epub 2020 Dec 15. PMID: 33325070.

Gordillo Altamirano F, Forsyth JH, Patwa R, Kostoulias X, Trim M, Subedi D, Archer SK, Morris FC, Oliveira C, Kielty L, Korneev D, O'Bryan MK, Lithgow TJ, Peleg AY, Barr JJ. Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials. Nat Microbiol. 2021 Feb;6(2):157-161. doi: 10.1038/s41564-020-00830-7. Epub 2021 Jan 11. PMID: 33432151.

Griffin DWJ, Bramwell E, Cheng AC, Spelman DW. Diagnostic testing for COVID-19: demonstrated utility of duplicate testing for inpatients in a low incidence setting. Intern Med J. 2020 Dec;50(12):1594-1595. doi: 10.1111/imj.15083. PMID: 33354876.

Vogel JP, Tendal B, Giles M, Whitehead C, Burton W, Chakraborty S, Cheyne S, Downton T, Fraile Navarro D, Gleeson G, Gordon A, Hunt J, Kitschke J, McDonald S, McDonnell N, Middleton P, Millard T, Murano M, Oats J, Tate R, White H, Elliott J, Roach V, Homer CSE; National COVID-19 Clinical Evidence Taskforce. Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce. Aust N Z J Obstet Gynaecol. 2020 Dec;60(6):840-851. doi: 10.1111/ajo.13270. Epub 2020 Oct 29. PMID: 33119139; PMCID: PMC7820999.

Department of Medicine - Alfred and Peninsula

Brewster DJ, Groombridge CJ, Gatward JJ. Consensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID-19 adult patient group. Med J Aust. 2021 Jan;214(1):46-46.e1. doi: 10.5694/mja2.50889. Epub 2020 Dec 8. PMID: 33295002.

Cordova LZ, Savage N, Ram R, Ellis L, Tobin V, Rozen WM, Seifman MA. Effects of COVID-19 lockdown measures on emergency plastic and reconstructive surgery presentations. ANZ J Surg. 2021 Feb 3. doi: 10.1111/ans.16625. Epub ahead of print. PMID: 33538101.

Melbourne Sexual Health Centre

Chow EPF, Hocking JS, Ong JJ, Phillips TR, Fairley CK. Sexually Transmitted Infection Diagnoses and Access to a Sexual Health Service Before and After the National Lockdown for COVID-19 in Melbourne, Australia. Open Forum Infect Dis. 2020 Nov 2;8(1):ofaa536. doi: 10.1093/ofid/ofaa536. PMID: 33506064; PMCID: PMC7665697.

Chow EPF, Hocking JS, Ong JJ, Phillips TR, Schmidt T, Buchanan A, Rodriguez E, Maddaford K, Fairley CK. Brief Report: Changes in PrEP Use, Sexual Practice, and Use of Face Mask During Sex Among MSM During the Second Wave of COVID-19 in Melbourne, Australia. J Acquir Immune Defic Syndr. 2021 Feb 1;86(2):153-156. doi: 10.1097/QAI.0000000000002575. PMID: 33433122; PMCID: PMC7808277.

Chow EPF, Ong JJ, Denham I, Fairley CK. HIV testing and diagnoses during the COVID-19 pandemic in Melbourne, Australia. J Acquir Immune Defic Syndr. 2020 Dec 16;Publish Ahead of Print. doi: 10.1097/QAI.0000000000002604. Epub ahead of print. PMID: 33346567.

Department of Surgery

Brown WA, Moore EM, Watters DA. Mortality of patients with COVID-19 who undergo an elective or emergency surgical procedure: a systematic review and meta-analysis. ANZ J Surg. 2020 Dec 27. doi: 10.1111/ans.16500. Epub ahead of print. PMID: 33369009.

Sun S, Ravintharan N, Jassal K, Nandurkar R, Yesul K, Boo E, Smit V, Fitzgerald M. COVID-19 pandemic consciousness: droplet contamination and aerosolization during pleural decompression. ANZ J Surg. 2020 Dec;90(12):2588-2591. doi: 10.1111/ans.16388. Epub 2020 Oct 14. PMID: 33030221; PMCID: PMC7675369.

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