16 Sept 2013

A new role discovered for a familiar enzyme: PI3K and the regulation of cell survival

In recent studies headed by Dr Mark Guthridge in the Leukemia Research Laboratory at the Australian Centre for Blood Diseases, Monash University and published in PLOS Biology, a new role was identified for the protein kinase activity of PI3K in regulating the “survival-only” response of human hematopoietic (blood) cells. These studies provide the first evidence that the protein kinase activity of PI3K can control cell survival and that this activity is a therapeutic target in cancer.
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