20 May 2022

Monash-led PADDI trial wins award

ACTA clinical trials 2022 awards were made on 20 May 2022,
International Clinical Trials Day. Professors Andrew Forbes (left)
and Tomas Corcoran (right) accepted the award for 'Excellence in
Trial Statistics' on behalf of the PADDI trial investigators.
The Perioperative Administration of Dexamethasone and Infection (PADDI) trial has been honoured by the 2022 Australian Clinical Trials Alliance (ACTA) Excellence in Trial Statistics Award.

The award was presented on International Clinical Trials Day, which is held on 20 May each year to recognise the outstanding contribution of the sector in developing and leading investigator-led clinical trials.

Nerve stimulation may be potential therapy for leaky gut diseases

Stimulating the vagal nerve may improve
gut permeability: study
by Anne Crawford

Research by Monash Central Clinical School scientists has suggested that stimulating the vagal nerve transcutaneously improves gut permeability and could potentially counter diseases caused by intestinal barrier dysfunction or ‘leaky gut’.  

Intestinal barrier dysfunction is likely to initiate diseases such as Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD) and Crohn’s disease.

3-16 May 2022 Central Clinical School recent publications

What is the estimated burden of healthcare associated infections
in Australian public hospitals? Study suggests it's high and
recommends robust, national coordinated surveillance.
Image: Public Health Notes

Recent publications featuring research as notified by PubMed during 3-16 May 2022 from Central Clinical School affiliated researchers in the following departments. The below is not a comprehensive list.

The most recent validated publications for the school and departments can be seen on their publications pages, linked to from the headings below. Otherwise, read down the entry for recent notifications.

19 May 2022

Research recognised on genital focused body image concerns

Congratulations to Dr Gemma Sharp, who was a finalist for Best International Paper in Aesthetic Surgery Journal

Her paper, titled "Genital self-image and aesthetic genital surgeries: Novel perspectives across the cisgender and transgender spectrum", showcases much of her own research on genital focused body image concerns and genital surgeries in cisgender women and men. This, she says, is a very under-recognised area in body image research, but has important impacts for psychological and sexual well-being as well as self-identity. In this paper, Dr Sharp calls for more research to be undertaken with people who identify as transgender who likely experience a complex interplay of gender dysphoria and genital body image concerns.

16 May 2022

Hot topics in MS research: our take on the 2022 MS Australia Scientific conference

L-R: Ms Pia Campagna, Dr Michael Zhong
Ms Pia Campagna and Dr Michael Zhong

Michael and I are third year PhD students in the Multiple Sclerosis and Neuroimmunology (MSNI) Genomics and Prognostics Group, led by Dr Vilija Jokubaitis. We recently attended the 2022 Progress in MS Research Scientific Conference in Hobart, convened by Prof. Helmut Butzkueven, Head of the Department of Neuroscience, Central Clinical School to present some of our work with academic peers and the wider non-academic community. 

The conference was organised by the peak national organisation for MS research, MS Australia. It has become a key forum for researchers and clinicians to come together and learn about the latest research happening around Australia, with the aim of stimulating innovative research and encouraging collaborations. 

Intestinal worm study highlights role of microbiota

by Anne Crawford

Monash Professor Nicola Harris has for 15 years investigated the intestinal activities of helminths (parasitic worms), making landmark discoveries about them as she did. Her latest paper, published recently in ‘Mucosal Immunology’, showed some surprising interactions between the intestinal microbiota and helminths that could offer a new approach to fighting the parasites and which reinforces the role of the microbiota.

Surgery registries crucial to improving patient care, researchers say

by Anne Crawford

Monash University Central Clinical School (CCS) clinician-researchers are behind a push for the Federal Government to urgently implement strategies to overcome barriers to clinical quality registries for surgery.

Registries systematically collect data on markers of quality of care for a given procedure across multiple sites, identifying times where the outcomes for patients are outside the normal range (good or bad) by risk adjusting and then benchmarking performance.  That information is then used to inform quality improvement initiatives for patients.

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