Hattapark's thesis is titled "The Role of Glutamate in the Pathogenesis of Acquired Epilepsy in Alzheimer's Disease". He was supervised by Professor Patrick Kwan and Associate Professor Nigel Jones, both in Department of Neuroscience at CCS.
He writes, "Alzheimer’s disease (AD) patients have up to 10-fold higher risk of developing epilepsy compared to healthy controls. However, the mechanism that links AD pathologies to epileptic seizures is not elucidated. We do know that disruption to glutamate-glutamine cycle in the brain caused by AD has the potential to enhance this risk.
