Australian Research Council grant successes for Central Clinical School were:
Dr Justin Hamilton, Australian Centre for Blood Diseases, has won a Future Fellowship totalling $745,744 over 5 years.
Dr Sebastian Dworkin, Department of Medicine, was awarded a Discovery Early Career Researcher Award totalling $383,066 over 3 years
See detail of their projects below.
Hamilton Project Summary
Pharmaceutical
inhibition of platelet function is the primary therapy for prevention
of arterial thrombosis – the most common cause of death and disability
in Australia. However, current therapies have limited efficacy. Defining
platelet activation mechanisms in order to rationalise more effective
antithrombotic approaches is the major focus of this research. This
project describes the first studies to examine the importance of a
family of intracellular signalling enzymes, the Class II
phosphoinositide 3-kinases, in platelet function. These studies will
define the contribution of these enzymes to platelet production and
function and will establish whether their inhibition is an attractive
strategy for the prevention of arterial thrombosis
Understanding
the genetic regulation of embryo formation is the cornerstone of
developmental biology. As four per cent of Australian children are born
with some form of prenatal defect, understanding the basic biology of
embryogenesis is paramount for long-range development of future
therapies. We have identified a highly conserved transcription factor,
Grhl3, which regulates multiple stages of embryonic formation. Using
advanced genetic models, this project will characterise the role of
Grhl3 in the regulation of cellular migration and craniofacial skeleton
and brain development. The project will also identify the target genes
which Grhl3 regulates. The identification of such transcriptional
networks is imperative to understanding the holistic molecular control
of embryogenesis.
All results can be seen at www.arc.gov.au.
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