20-26 Oct 2020 Central Clinical School publications

Dr Maithili Sashindranath is senior author on a study looking at
at different stroke mouse models for improved stroke therapies.
You can follow @dr_maithili on Twitter

Recent publications featuring research as notified by PubMed during 20-26 October 2020 from Central Clinical School affiliated researchers in the following departments. The below is not a comprehensive list:

• Allergy, Immunology and Respiratory Medicine
• Anaesthesiology and Perioperative Medicine
  
• Australian Centre for Blood Diseases
• Immunology and Pathology
  
• Infectious Diseases
• Medicine - Alfred & Peninsula
• Melbourne Sexual Health Centre
• Neuroscience
• Psychiatry

Department of Allergy, Immunology and Respiratory Medicine

Earnest A, Salimi F, Wainwright CE, ..., Kotsimbos T, Ahern S. Lung function over the life course of paediatric and adult patients with cystic fibrosis from a large multi-centre registry. Sci Rep. 2020 Oct 15;10(1):17421. doi: 10.1038/s41598-020-74502-1. PMID: 33060788; PMCID: PMC7567842.

Joosten SA, Tan M, Wong AM, ..., Sands SA, ..., Edwards BA. A randomized controlled trial of oxygen therapy for patients who do not respond to upper airway surgery for obstructive sleep apnea. J Clin Sleep Med. 2020 Oct 23. doi: 10.5664/jcsm.8920. Epub ahead of print. PMID: 33094725.


Department of Anaesthesiology and Perioperative Medicine

Beattie WS, Lalu M, Bocock M, ..., Myles P; StEP COMPAC Group; Patient Comfort; Clinical Indicators; Delirium Postoperative Cognitive Dysfunction Stroke; Cardiovascular; Data Extractors; Respiratory; Inflammation Sepsis; Acute Kidney Injury; Bleeding Complications Patient Blood Management; Healthcare Resource Utilisation; Patient-Centred Outcomes; Organ Failure and Survival; Cancer Surgery. Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes. Br J Anaesth. 2020 Oct 19:S0007-0912(20)30780-7. doi: 10.1016/j.bja.2020.09.023. Epub ahead of print. PMID: 33092804.


Australian Centre for Blood Diseases

Amann-Zalcenstein D, Tian L, Schreuder J, ..., McCormack MP, ..., Naik SH. A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics. Nat Immunol. 2020 Oct 19. doi: 10.1038/s41590-020-0799-x. Epub ahead of print. PMID: 33077975.

Das TP, Kipp DA, Kliman DS, Patil SS, Curtis DJ, ..., Spencer A. Important factors in implementation of lineage-specific chimerism analysis for routine use. Bone Marrow Transplant. 2020 Oct 21. doi: 10.1038/s41409-020-01089-6. Epub ahead of print. PMID: 33082555.

Dickins RA. Rerouting DOT1L inhibitors in leukemia. Blood. 2020 Oct 22;136(17):1900-1901. doi: 10.1182/blood.2020007352. PMID: 33091135.

Goh W, Scheer S, Jackson JT, ..., McCormack MP, Nutt SL, Huntington ND. Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance. Cell Rep. 2020 Oct 20;33(3):108285. doi: 10.1016/j.celrep.2020.108285. PMID: 33086067.

Lee NT, Selan C, Chia JSJ, Sturgeon SA, Wright DK, Zamani A, Pereira M, Nandurkar HH, Sashindranath M. Characterization of a novel model of global forebrain ischaemia-reperfusion injury in mice and comparison with focal ischaemic and haemorrhagic stroke. Sci Rep. 2020 Oct 23;10(1):18170. doi: 10.1038/s41598-020-75034-4. PMID: 33097782.

Morrish E, Copeland A, Moujalled DM, Powell JA, Silke N, Lin A, Jarman KE, Sandow JJ, Ebert G, Mackiewicz L, Beach JA, Christie EL, Lewis AC, Pomilio G, Fischer KC, MacPherson L, Bowtell DDL, Webb AI, Pellegrini M, Dawson MA, Pitson SM, Wei AH, Silke J, Brumatti G. Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models. Blood Adv. 2020 Oct 27;4(20):5062-5077. doi: 10.1182/bloodadvances.2020001576. PMID: 33080008.


Department of Gastroenterology

Chey WD, Keefer L, Whelan K, Gibson PR. Behavioral and Diet Therapies in Integrated Care for Patients with Irritable Bowel Syndrome. Gastroenterology. 2020 Oct 19:S0016-5085(20)35281-1. doi: 10.1053/j.gastro.2020.06.099. Epub ahead of print. PMID: 33091411.

Freeman E, Cheung W, Majeed A, Kemp W, Roberts SK. Irreversible Electroporation For Hepatocellular Carcinoma: Longer-Term Outcomes At A Single Centre. Cardiovasc Intervent Radiol. 2020 Oct 13. doi: 10.1007/s00270-020-02666-4. Epub ahead of print. PMID: 33051707.

Iacovou M, Gibson PR, Muir JG. Dietary Changes Among Breastfeeding Mothers. J Hum Lact. 2020 Oct 15:890334420959283. doi: 10.1177/0890334420959283. Epub ahead of print. PMID: 33054509.

Nguyen ALH, Sparrow MP. Evolving Role of Thiopurines in Inflammatory Bowel Disease in the Era of Biologics and New Small Molecules. Dig Dis Sci. 2020 Oct 19. doi: 10.1007/s10620-020-06662-z. Epub ahead of print. PMID: 33073334.

Roberts SK, Strasser SI, Nicoll AJ, Kemp W, Majeed A, Mitchell J, Stuart K, Gow P, Sood S, MacQuillan G, George J, Mitchell J, McCaughan GW; ALA Clinical Research Network. Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis. Scand J Gastroenterol. 2020 Oct 17:1-9. doi: 10.1080/00365521.2020.1821764. Epub ahead of print. PMID: 33070650.

Tuck CJ, De Palma G, Takami K, Brant B, Caminero A, Reed DE, Muir JG, Gibson PR, Winterborn A, Verdu EF, Bercik P, Vanner S. Nutritional profile of rodent diets impacts experimental reproducibility in microbiome preclinical research. Sci Rep. 2020 Oct 20;10(1):17784. doi: 10.1038/s41598-020-74460-8. PMID: 33082369; PMCID: PMC7575541.

Yao CK, Burgell RE, Taylor KM, Ward MG, Friedman AB, Barrett JS, Muir JG, Gibson PR. Effects of fiber intake on intestinal pH, transit and predicted oral mesalamine delivery in patients with ulcerative colitis. J Gastroenterol Hepatol. 2020 Oct 22. doi: 10.1111/jgh.15311. Epub ahead of print. PMID: 33091174.

Zhang J, Lay RJ, Roberts SK, Chauhan S. Towards real-time finite-strain anisotropic thermo-visco-elastodynamic analysis of soft tissues for thermal ablative therapy. Comput Methods Programs Biomed. 2020 Oct 8;198:105789. doi: 10.1016/j.cmpb.2020.105789. Epub ahead of print. PMID: 33069033.


Department of Immunology and Pathology

Goodall KJ, Nguyen A, McKenzie C, Eckle SBG, Sullivan LC, Andrews DM. The murine CD94/NKG2 ligand, Qa-1b, is a high-affinity, functional ligand for the CD8αα homodimer. J Biol Chem. 2020 Mar 6;295(10):3239-3246. doi: 10.1074/jbc.RA119.010509. Epub 2020 Jan 28. PMID: 31992596; PMCID: PMC7062157.

Hartley GE, Edwards ESJ, Bosco JJ, Ojaimi S, Stirling RG, Cameron PU, Flanagan K, Plebanski M, Hogarth PM, O'Hehir RE, van Zelm MC. Influenza-specific IgG1+ memory B-cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency. Clin Transl Immunology. 2020 Oct 16;9(10):e1199. doi: 10.1002/cti2.1199. PMID: 33088507; PMCID: PMC7563650.

Raftery AL, Tsantikos E, Harris NL, Hibbs ML. Links Between Inflammatory Bowel Disease and Chronic Obstructive Pulmonary Disease. Front Immunol. 2020 Sep 11;11:2144. doi: 10.3389/fimmu.2020.02144. PMID: 33042125; PMCID: PMC7517908.


Department of Infectious Diseases

McMahon JH, Hoy JF, Kamarulzaman A, Bekker LG, Beyrer C, Lewin SR. Leveraging the advances in HIV for COVID-19. Lancet. 2020 Oct 3;396(10256):943-944. doi: 10.1016/S0140-6736(20)32012-2. PMID: 33010825; PMCID: PMC7529395.

Dr James McMahon is leading a study to find out whether an

antiviral called favipiravir will help people with COVID-19

with COVID-clear the virus from their systems faster. 
Video explainer

McMahon JH, Lau JSY, Roney J, Rogers BA, Trubiano J, Sasadeusz J, Molton JS, Gardiner B, Lee SJ, Hoy JF, Cheng A, Peleg AY. An adaptive randomised placebo controlled phase II trial of antivirals for COVID-19 infection (VIRCO): A structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Oct 13;21(1):847. doi: 10.1186/s13063-020-04766-5. PMID: 33050947; PMCID: PMC7552590.

Saag MS, Gandhi RT, Hoy JF, ..., Volberding PA. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2020 Oct 14. doi: 10.1001/jama.2020.17025. Epub ahead of print. PMID: 33052386.


Department of Medicine - Alfred & Peninsula

Dalli LL, Kim J, Thrift AG, Andrew NE, ..., Lannin NA, ..., Kilkenny MF; AuSCR Consortium. Patterns of use and discontinuation of secondary prevention medications after stroke. Neurology. 2020 Oct 22:10.1212/WNL.0000000000011083. doi: 10.1212/WNL.0000000000011083. Epub ahead of print. PMID: 33093227.

McAuley SA, Lee MH, Paldus B, ..., Bach LA, ..., O'Neal DN; Australian JDRF Closed-Loop Research Group. Six Months of Hybrid Closed-Loop Versus Manual Insulin Delivery With Fingerprick Blood Glucose Monitoring in Adults With Type 1 Diabetes: A Randomized, Controlled Trial. Diabetes Care. 2020 Oct 14:dc201447. doi: 10.2337/dc20-1447. Epub ahead of print. PMID: 33055139.

Williams TJ, McGiffin D. 'Surgery first' if cure is your aim in CTEPH. Respirology. 2020 Oct 18. doi: 10.1111/resp.13956. Epub ahead of print. PMID: 33073458.


Melbourne Sexual Health Centre

Phillips TR, Fairley CK, Bradshaw CS, Hocking JS, Choi EPH, Ong JJ, Tabesh M, Maddaford K, Chow EPF. Group sex among men who have sex with men in the era of PrEP: A cross-sectional study. J Acquir Immune Defic Syndr. 2020 Oct 19. doi: 10.1097/QAI.0000000000002550. Epub ahead of print. PMID: 33093332.

Sumarno V, Temple-Smith MJ, Bilardi JE. Whose role is it? Primary care and the provision of emotional support for women experiencing miscarriage: a pilot qualitative Australian study. Aust J Prim Health. 2020 Oct;26(5):388-395. doi: 10.1071/PY20042. PMID: 32972509.

Tang W, Wang Y, Huang W, ..., Ong JJ, ... Tucker JD. Adolescent and non-consensual anal sexual debut among Chinese men who have sex with men: a cross-sectional study. BMC Infect Dis. 2020 Oct 7;20(1):732. doi: 10.1186/s12879-020-05466-w. PMID: 33028241; PMCID: PMC7541224.

Wang C, Wang YJ, Tucker JD, ..., Ong JJ, Zheng HP, Yang B. Correlates of HIV self-testing among female sex workers in China: implications for expanding HIV screening. Infect Dis Poverty. 2020 Oct 22;9(1):147. doi: 10.1186/s40249-020-00765-5. PMID: 33092641; PMCID: PMC7583185.

Zou Z, Fairley CK, Ong JJ, Hocking J, Canfell K, Ma X, Chow EPF, Xu X, Zhang L, Zhuang G. Domestic HPV vaccine price and economic returns for cervical cancer prevention in China: a cost-effectiveness analysis. Lancet Glob Health. 2020 Oct;8(10):e1335-e1344. doi: 10.1016/S2214-109X(20)30277-1. PMID: 32971056.


Department of Neuroscience

Alsfouk BAA, Hakeem H, Chen Z, Walters M, Brodie MJ, Kwan P. Characteristics and treatment outcomes of newly diagnosed epilepsy in older people: A 30-year longitudinal cohort study. Epilepsia. 2020 Oct 23. doi: 10.1111/epi.16721. Epub ahead of print. PMID: 33098099.

Butzkueven H, Licata S, Jeffery D, Arnold DL, Filippi M, Geurts JJ, Santra S, Campbell N, Ho PR; REVEAL Investigators. Natalizumab versus fingolimod for patients with active relapsing-remitting multiple sclerosis: results from REVEAL, a prospective, randomised head-to-head study. BMJ Open. 2020 Oct 20;10(10):e038861. doi: 10.1136/bmjopen-2020-038861. PMID: 33082194; PMCID: PMC7577060.

Campbell BCV, Mitchell PJ, Churilov L, ..., Cloud GC, ..., Davis SM; EXTEND-IA TNK Part 2 investigators. Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial. JAMA. 2020 Apr 7;323(13):1257-1265. doi: 10.1001/jama.2020.1511. PMID: 32078683; PMCID: PMC7139271.

Orchard ER, Ward PGD, Chopra S, Storey E, Egan GF, Jamadar SD. Neuroprotective Effects of Motherhood on Brain Function in Late Life: A Resting-State fMRI Study. Cereb Cortex. 2020 Oct 17:bhaa293. doi: 10.1093/cercor/bhaa293. Epub ahead of print. PMID: 33067999.

"...motherhood may be beneficial for brain function in late life. " Surprise!

Zhong M, van der Walt A, Campagna MP, Stankovich J, Butzkueven H, Jokubaitis V. The Pharmacogenetics of Rituximab: Potential Implications for Anti-CD20 Therapies in Multiple Sclerosis. Neurotherapeutics. 2020 Oct 14. doi: 10.1007/s13311-020-00950-2. Epub ahead of print. PMID: 33058021.


Department of Psychiatry

Chen L, Hudaib AR, Hoy KE, Fitzgerald PB. Efficacy, efficiency and safety of high-frequency repetitive transcranial magnetic stimulation applied more than once a day in depression: A systematic review. J Affect Disord. 2020 Dec 1;277:986-996. doi: 10.1016/j.jad.2020.09.035. Epub 2020 Sep 11. PMID: 33065843.

Thomas EHX, Steffens M, Harms C, Rossell SL, Gurvich C, Ettinger U. Schizotypy, neuroticism, and saccadic eye movements: New data and meta-analysis. Psychophysiology. 2020 Oct 23:e13706. doi: 10.1111/psyp.13706. Epub ahead of print. PMID: 33095460.


Department of Surgery

Stephens AF, Gregory SD, Burrell AJC, Marasco S, Stub D, Salamonsen RF. Physiological Principles of Starling-Like Control of Rotary Ventricular Assist Devices. Expert Rev Med Devices. 2020 Oct 23. doi: 10.1080/17434440.2020.1841631. Epub ahead of print. PMID: 33094673.

Tracy LM, Singer Y, Schrale R, ..., Cleland H, Gabbe BJ. Epidemiology of burn injury in older adults: An Australian and New Zealand perspective. Scars Burn Heal. 2020 Sep 29;6:2059513120952336. doi: 10.1177/2059513120952336. PMID: 33062309; PMCID: PMC7534068.