- Speaker: Professor Merlin Thomas
- Monday 2 August 12.30-1.30 pm
- Click here to start or join. Or, go to https://monash.zoom.us/join and enter meeting ID: 836 5090 3890 and passcode: 317325
- CCS calendar entry link
RNA therapeutics are a disruptive technology with the potential to actualize personalized medicine. Most RNA does not encode sequences for protein synthesis (mRNA; e.g. for vaccines). These other functions can be harnessed to selectively modulate protein expression by silencing, binding as aptamers and altering mRNA splicing. As an example, we are developing an oligonucleotide that modulates the alternate splicing of the Receptor for Advanced Glycation End-products (RAGE), a key therapeutic target in Alzheimer’s disease.
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