Showing posts with label Department of Immunology. Show all posts
Showing posts with label Department of Immunology. Show all posts

7 Aug 2023

Meet Dr Anouk von Borstel

A lecturer’s enthusiasm for immunology rubbed off on Anouk during her undergraduate studies, and she pursued this interest in her Masters of Science and PhD. Having maintained her passion for translational immunology and experiencing firsthand the excitement of making new discoveries, translational research became the common thread throughout her scientific career. She left her native Netherlands to join a structural biology lab at Monash University’s Biomedical Discovery Institute (BDI) in 2018, where she published two lead author papers and co-authored nine more, before joining the Allergy and Clinical Immunology Laboratory within Central Clinical School’s Department of Immunology. There she is currently focused on studying the allergic immune response and how this is altered when patients are treated with allergen immunotherapy.

How did you become interested in immunology? What excites you about this area?

My passion for immunology began during my lectures in my BSc studies, where I was fortunate to have a professor whose enthusiasm for the subject was infectious. His ability to convey the complexities of the immune system with true passion left me amazed and wanting to learn more about it.

What truly excites me about this area is the vast amount of uncharted territory. Despite significant progress, there is still so much we don’t fully understand about the immune system. Moreover, the prospect of contributing to the growing body of knowledge and making a positive impact on human health keeps me motivated.

12 Aug 2022

Congratulations to Menno van Zelm on his promotion to Professor

Congratulations to Menno van Zelm in the Department of Immunology on his promotion to Professor! The University's Professorial Promotions Committee said that they recognised his significant contribution to the University in the areas of academic activity: research and engagement. They wrote, "In particular, the Committee noted your contributions to commercialisation and patents."

Professor van Zelm has also been successful this year in obtaining NHMRC MRFF funding of $6.3M for a study of COVID-19 vaccines and infection with the goal of improving the care and outcomes for children and people with chronic diseases, particularly as future variants emerge. See faculty story

18 Feb 2020

Findings may boost hay fever therapy

L-R: Dr Craig McKenzie, Prof Robyn O'Hehir,
Associate Professor Menno van Zelm
by Anne Crawford

Allergen immunotherapy is the only treatment to modify the natural course of allergy to ryegrass pollen – or spring hay fever – rather than just alleviating symptoms. Treatment involves repeated exposure of patients to allergen extracts either by injection or tablet, ‘training’ the immune system to clear these allergens without generating an allergic response.

But it’s not known exactly how this immunotherapy works.

15 Nov 2019

Translational study on high-fibre diet an eye-opener for PhD science student

Paul Gill, PhD student, has published his

first paper investigating the influence of a
high-fibre diet on SCFAs in the blood.
Follow Paul on Twitter @gillpaul93
by Anne Crawford

When PhD candidate Paul Gill began his biomedical science course at Monash University he had no idea his studies would immerse him in one of the most dynamic fields of contemporary science: the gut microbiome.

Paul’s first paper, recently published in The European Journal of Nutrition, highlighted the potential of dietary fibre therapy to manipulate the production of short chain fatty acids (SCFA) and blood plasma concentrations. SCFAs are a group of organic acids produced in the gut from the bacterial fermentation of fibre in fruit, vegetables and certain grains. They are important for gut health but then absorbed into the bloodstream.

8 May 2019

Platform Access Grants Success!

Jess Borger, Tiffany Bouchery and Emily Edwards

Congratulations to Emily Edwards, Jess Borger and Tiffany Bouchery who recently received Platform Access Grants  from the Faculty of Medicine, Nursing and Health Sciences.  The scheme is an initiative to encourage research development through engagement with the FMNHS technology research platforms, with a view to strengthen researchers capability and international competitiveness. The seed funding also aims at attracting external national and international competitive grants.


Grant win for Dr Bridgette Semple

Congratulations to Dr Bridgette Semple, who has been awarded the 2019 Capstone Editing Grant for Mid-Career Researchers!
Dr Bridgette Semple (left)

Capstone Editing, an Australian academic editing company, supports one researcher annually to undertake an innovative research project with a view to gathering preliminary data that will lead to the development of a research council funding application.

Dr Semple is the Head of the Paediatric Neurotrauma Group in the Department of Neuroscience.  Her research focuses on traumatic brain injury, particularly during early childhood. The funds from this grant will assist with her collaboration with Associate Professor Margaret Hibbs from the Immunology Department.  They will investigate the role of the SHIP-1 enzyme, which is yet to be explored in the brain.


15 Nov 2018

Research spotlight on: Dr Emily Edwards, helping people with primary immunodeficiencies

Watch the video here: https://youtu.be/por0jc2dSnk
Dr Emily Edwards, Department of Immunology and Pathology, discusses her work on investigating the impact of genetic mutations on B cell differentiation and function in patients with primary immunodeficiencies.

This year, Emily has presented at the launch of the JMF Centre for Primary Immunodeficiencies Melbourne. She also a recipient of an international travel award from the British Society of Immunology.

Recently, Emily spoke to Dr Shane Huntington on RRR's "Einstein A Go-Go".
Listen: www.rrr.org.au/explore/programs/einstein-a-go-go/episodes/5373-einstein-a-go-go-11-november-2018

See more:

19 Oct 2018

Recent CCS publications: 8 - 13 Oct 2018

MRFF recipient Prof Andrew Spencer
discusses his research on Multiple Myeloma
Recent publications for Central Clinical School affiliated authors in the following departments. Note, browse down this entry for complete publications list. Linked headings for each section are to the departments' home pages.
  • Australian Centre for Blood Diseases (ACBD)
  • Diabetes 
  • Gastroenterology
  • Immunology and Pathology
  • Infectious Diseases
  • MAPrc
  • Melbourne Sexual Health Clinic
  • Neuroscience
  • Surgery

12 Oct 2018

Recent CCS publications: 25 September - 7 October 2018

Head of Surgery, Prof Wendy Brown
co-authored a paper on long-term outcomes
of lap-banding surgery. She is also giving a
CCS Public Lecture, Thurs 18 Oct. 
Recent publications for Central Clinical School affiliated authors in the following departments. Note, browse down this entry for complete publications list. Linked headings for each section are to the departments' home pages.
  • Allergy, Immunology and Respiratory Medicine
  • Anaesthesia and Perioperative Medicine
  • Australian Centre for Blood Diseases (ACBD)
  • Diabetes 
  • Immunology and Pathology
  • Infectious Diseases
  • MAPrc
  • Medicine
  • Neuroscience
  • NTRI
  • Surgery

9 Dec 2016

CCS Doctoral student profile - Timothy Gottschalk

Tim Gottschalk participating in the CCS
Postgraduate Student Symposium 2016
By Eliza Watson

Timothy Gottschalk is a PhD student in the Leukocyte Signaling Laboratory at the Department of Immunology and Pathology where he is supervised by Associate Professor Margaret Hibbs. He studied a Bachelor of Biomedical Science and is interested in learning about what causes and drives autoimmune disease.

22 Apr 2016

Explore ‘Immunology heroes and villains’ at the annual Day of Immunology 29 April 2016

Image at the DoI photo exhibition opening 21 April at St Ali Cafe
in Melbourne. "T cells see red, cancer immunotherapy to the rescue.
A snapshot of a melanoma tumour. " Dani Tutuka, 
from the Olivia Newton-John Cancer Research Institute.
Celebrate and learn more about the immune system with public lectures, tours and ‘vaccination café’.

Since 2005, The Day of Immunology has celebrated and explored the highly sophisticated human immune system, the mysteries of which are still being unravelled. The complex system guards against infection, but can also attack the body it is designed to protect. The Day of Immunology aims to strengthen awareness on the importance of the immune system and promote scientific research.

26 Feb 2016

Immune system 'patrolling' cells further understood

By Dr Jodie Abramovitch

Within the immune system there are patrolling cells that are constantly scanning the body for signs of infection. They are known as antigen presenting cells. Dendritic cells (DC) are the most efficient example of an antigen presenting cell. When DC find an infection, they are able to alert other cells of the immune system to attack and destroy the infection. Therefore the functions of DC are really important in an effective immune response.

Associate Professor Mark Wright, Head of
the Leucocyte Membrane Protein Group
and senior author of this study
Tetraspanins are a type of protein that are found at the cell surface. Here they bind and bring together (“organise”) other proteins and receptors at the cell surface. CD37 and CD82 are tetraspanins that allow DC to communicate with other immune cells that there is an infection present. CD37 is important for movement of DC to lymph nodes where they find other immune cells. The role of CD82 in DC migration is unclear.

In a recent study published by the Leucocyte Membrane Protein laboratory from the Department of Immunology and Pathology, in collaboration with Melbourne University and international colleagues, the roles of CD37 and CD82 in co-ordinating DC function in response to infection was assessed.

By studying activated DC, it was found that CD82 appeared to have an opposing function to CD37. Whereas CD37 expression was down-regulated following activation of DC, CD82 was up-regulated and restrained DC migration to lymph nodes. DC that were deficient in either CD37 or CD82 were unable to become fully functional and DC that were deficient in CD82 were able to spread much further than CD37 deficient DC. Thus, unactivated DC were observed to have high CD37 expression and low CD82 expression leading to a highly mobile cell that is able to travel easily around the body. Activated DC (DC that have sensed an infection) have low CD37 expression and high CD82 expression which limits mobility of the DC but is able to efficiently signal to immune cells that an infection is present.

This study has detailed a biology of DC that was not previously known and highlights the importance of tetraspanins in coordinating DC function. 


Reference: Jones EL, Wee JL, Demaria MC, Blakeley J, Ho PK, Vega-Ramos J, Villadangos JA, van Spriel AB, Hickey MJ, Hämmerling GJ, Wright MD. Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37. J Immunol. 2016 Feb: 196; 978-87. 
doi: 10.4049/jimmunol.1500357

16 Nov 2015

A cardiorenal drug helps in diabetic retinopathy

Dr Devy Deliyanti, lead author and Prof
Jenny Wilkinson-Berka, last author.
A Monash University-Melbourne University collaboration has found that FT011, a novel cardiorenal protective drug, reduces inflammation, gliosis and vascular injury in rats with diabetic retinopathy.

4 Nov 2015

Congratulations to Dr Mutsa Madondo on his recent PhD award!

Congratulations to Dr Mutsa Madondo who graduated Friday 30 October 2015. His thesis title is "Immunomodulatory effects of cyclophosphamide: optimising treatment for improved efficacy in patients with refractory gynaecological cancers", supervised by Prof Magdalena Plebanski, head of Vaccine and Infectious Diseases Laboratory and Dr Sue Xiang in the Department of Immunology.

Mutsa's thesis investigated the effects of cyclophosphamide (a chemotherapy drug) on the immune system of patients with gynaecological cancers. It found that the drug was able to promote activation of specific immune cells that are capable of killing tumour cells. The drug also enabled these cells to migrate towards the tumour. These findings were associated with improved patient survival and disease stability. This research also identified differences between patients that responded to treatment and those that did not, and found new targets that could potentially improve treatment outcomes for patients.

Mutsa is now a postdoctoral fellow in Prof Plebanski's lab continuing to work on understanding immune suppression in gynaecological cancer patients.

1 May 2015

7 May Seminar: The tetraspanin CD82 and autophagy - its role in host defense

This Special Seminar will be held 12‐1pm on Thursday 7 May 2015 in the AMREP Education Centre Lecture theatre. All welcome.

A/Prof Jatin Vyas from the Harvard Medical School, USA will speak on "The tetraspanin CD82 and autophagy - its role in host defense". Prof Vyas’ laboratory has expertise in the interactions between dendritic cells and fungal pathogens, focusing on the role of Dectin-1, LC-3 (member of the autophagy family of proteins), Toll-like receptors and tetraspanins and their effects on phagosomal maturation. Please join us after the seminar for light refreshments.

See more about the Department of Immunology seminars: www.med.monash.edu.au/immunology/teaching/seminars.html
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