Congratulations to all of our recently promoted researchers!

Congratulations to our fifteen academic staff - researchers and lecturers - who have recently received a promotion. 

Professor Terry O'Brien, Head of School said, "Warmest congratulations to everyone who has been promoted. 

"This is a wonderful outcome, not only for our individual researchers and teachers, but how it represents the extraordinary talent and energy of the entire school."

See detail and links below.

Cross-disciplinary research links golden staph to autoimmune disease

Prof. Peleg with his lab group.

Professor Anton Peleg, Director of Infectious Diseases, recently collaborated on a paper published in Nature Communications.

The study found that the body may be fooled by a plasmid-derived protein from some types of Staph aureus (golden staph), resulting in the development of severe autoimmune disease. Plasmids have been associated with antibiotic resistance but this study now links them to autoimmune disease, specifically ANCA-associated vasculitis (AAV), a severe autoimmune disease caused by autoimmunity to myeloperoxidase (MPO).

Combatting superbugs – potential role of combination antibiotic therapy

By Dr Jodie Abramovitch

Infections caused by drug resistant (methicillin-resistant) Staphylococcus aureus (MRSA), a type of bacteria, can have serious health consequences. These infections are typically found in hospitals but can also occur within the community. MRSA is known as a superbug because it is able to survive many types of antibiotic treatments. 

Prof. Anton Peleg

Daptomycin is a ‘last-line’ antibiotic and is commonly used in the treatment of MRSA infections. However, there is evidence that daptomycin is unable to treat some MRSA infections which means alternative treatments are urgently required to prevent the spread of infection.

Monash researchers Dr Jhih-Hang Jiang and Professor Anton Peleg (Head of the Department of Infectious Diseases) study hospital-acquired infections and have recently focussed on how to combat daptomycin-resistant S. aureus. Samples of S. aureus from patients with infections were isolated and treated with different antibiotics, alone and in combination. When treated with both daptomycin and another antibiotic called gentamicin, antibiotic-resistant S. aureus was more effectively killed when compared to daptomycin treatment alone. However, it was noted that this approach may be associated with toxic side effects when used in patients.

This study concluded that combination therapy is an effective way to treat and limit the emergence of antibiotic-resistant strains of S. aureus, particularly in deep-seated, complicated infections. Further research is still required to balance the benefits of this approach with the potential risks. 

Reference: Jiang JH, Peleg AY. Daptomycin-Nonsusceptible Staphylococcus aureus: The Role of Combination Therapy with Daptomycin and Gentamicin. Genes (Basel). 2015 Nov; 6:1256-67