14 Feb - 14 Mar 2022 Central Clinical School recent publications

Professor Rob Medcalf was interviewed for an Anesthesiology

podcast on featured research on fibrinolysis and trauma outcomes.

See podcast transcript and Medcalf-Myles editorial. 

Recent publications featuring research as notified by PubMed during 14 February - 14 March 2022 from Central Clinical School affiliated researchers in the following departments. The below is not a comprehensive list, there are too many!

 The most recent validated publications for the school and departments can be seen on their publications pages, linked to from the headings below. Otherwise, read down the entry for recent notifications.

Can delirium after major surgery be reduced by tranexamic acid?

ANZCA funded study will look at whether tranexamic acid can
reduce confusion and delirium after major surgery.

Congratulations to Professor Paul Myles on his grant from the Australia and New Zealand College of Anaesthetists (ANZCA) of $120,000 over two years for the project "Tranexamic acid to reduce delirium after gastrointestinal surgery: the TRIGS-D trial".

Delirium is a devastating complication of medical and surgical care, associated with increased morbidity and mortality, dementia and impaired long-term cognition, and loss of independence. 

Finding a therapeutic target for Cerebral Amyloid Angiopathy

Professor Geoffrey Cloud

by Loretta Piccenna, PhD
Research Manager, Department of Neuroscience, Central Clinical School

 An opinion piece published in the journal Stroke proposes the re-purposing of a potent existing drug, tranexamic acid (TXA), for the treatment of cerebral amyloid angiopathy (CAA), a devastating cause of stroke due to intracerebral haemorrhage and dementia.  

Professor Geoffrey Cloud, Director of Stroke Services, Alfred Health and Group leader, Department of Neuroscience at the Central Clinical School, said, 

‘Cerebral amyloid angiopathy (CAA) is a neurological condition that is increasingly being diagnosed in clinical practice, but sadly there is no specific treatment for patients.’