Advancing new therapeutic targets for people with drug-resistant epilepsy

By Dr Loretta Piccenna, Department of Neuroscience

Epilepsy & Behaviour group

To make significant research advances to improve outcomes for people with drug-resistant epilepsy, researchers need to understand the molecular and neurobiological processes that occur within the brain to enable them to identify new therapeutic targets.

Researchers from the Epilepsy & Behaviour research group in the Department of Neuroscience have moved a step closer to this goal by publishing findings to show that a pre-clinical mouse model, known as the self-sustained Electrical Status Epilepticus (SSSE) mouse model, strongly resembles features seen and experienced by patients with drug-resistant mesial Temporal Lobe Epilepsy.