People with depression who are also overweight are more likely to have chronic symptoms. It may be that inflammation and high insulin levels associated with being overweight make depression worse. Metformin in a medication usually used for diabetes that lowers inflammation and insulin levels and has been shown to help with weight loss. The
Monash Alfred Psychiatry Research centre is investigating the effectiveness of metformin in combination with standard antidepressants at causing weight loss and improving depressive symptoms.
