By Dr Jodie Abramovitch
Autoimmune disease occurs when the immune system incorrectly
recognises self-tissues and organs as being potentially dangerous - like a
pathogen. The immune system attacks the tissue or organ – sometimes in an
organ-specific manner (eg. type I diabetes) or sometimes in a multi-organ
fashion (eg. lupus) – which leads to disease symptoms. What causes the onset of
autoimmune disease is not well understood and, consequently, there is no cure
with treatments predominantly aimed at relieving inflammatory symptoms.
Elisha de Valle - first author of this study |
This study revealed that NF-κB1 has an essential role in controlling
the function of Fo B cells, primarily to limit the production of inflammatory factor
IL-6. In the absence of NF-κB1, the production of IL-6 becomes deregulated and severe autoimmune disease can
occur. These conclusions further the understanding of the mechanisms that control IL-6 production and may lead to better management of
patients with autoimmune disease.
Reference: de Valle E, Grigoriadis G, O'Reilly LA, Willis SN, Maxwell MJ, Corcoran LM, Tsantikos E, Cornish JK, Fairfax KA, Vasanthakumar A, Febbraio MA, Hibbs ML, Pellegrini M, Banerjee A, Hodgkin PD, Kallies A, Mackay F, Strasser A, Gerondakis S, Gugasyan R. NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med. 2016 Apr; 213:621-41.
doi: 10.1084/jem.20151182.
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